CSN8_EMENI
ID CSN8_EMENI Reviewed; 212 AA.
AC P0C624; C8VMC3;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 25-MAY-2022, entry version 57.
DE RecName: Full=COP9 signalosome complex subunit 8;
DE Short=CSN complex subunit 8;
GN Name=csnH; Synonyms=csn8; ORFNames=AN10208;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
RN [3]
RP IDENTIFICATION IN THE CSN COMPLEX, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=17470786; DOI=10.1073/pnas.0702108104;
RA Busch S., Schwier E.U., Nahlik K., Bayram O., Helmstaedt K., Draht O.W.,
RA Krappmann S., Valerius O., Lipscomb W.N., Braus G.H.;
RT "An eight-subunit COP9 signalosome with an intact JAMM motif is required
RT for fungal fruit body formation.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:8089-8094(2007).
CC -!- FUNCTION: Component of the COP9 signalosome (CSN) complex that acts as
CC an regulator of the ubiquitin (Ubl) conjugation pathway by mediating
CC the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-
CC protein ligase complexes (By similarity). The CSN complex seems to link
CC protein degradation to sexual development. {ECO:0000250}.
CC -!- SUBUNIT: Component of the COP9 signalosome (CSN) complex.
CC {ECO:0000269|PubMed:17470786}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CSN8 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AACD01000022; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AACD01000022; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BN001307; CBF84891.1; -; Genomic_DNA.
DR AlphaFoldDB; P0C624; -.
DR SMR; P0C624; -.
DR DIP; DIP-60932N; -.
DR IntAct; P0C624; 1.
DR STRING; 162425.CADANIAP00008069; -.
DR EnsemblFungi; CBF84891; CBF84891; ANIA_10208.
DR eggNOG; ENOG502SG50; Eukaryota.
DR HOGENOM; CLU_108986_0_0_1; -.
DR InParanoid; P0C624; -.
DR OMA; LRAVWQT; -.
DR OrthoDB; 1577916at2759; -.
DR Proteomes; UP000000560; Chromosome VII.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0008180; C:COP9 signalosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0010387; P:COP9 signalosome assembly; IEA:InterPro.
DR GO; GO:0000338; P:protein deneddylation; IEA:InterPro.
DR InterPro; IPR033205; COP9_CSN8.
DR InterPro; IPR033464; CSN8_PSD8_EIF3K.
DR InterPro; IPR000717; PCI_dom.
DR PANTHER; PTHR13339; PTHR13339; 1.
DR Pfam; PF10075; CSN8_PSD8_EIF3K; 1.
DR PROSITE; PS50250; PCI; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT CHAIN 1..212
FT /note="COP9 signalosome complex subunit 8"
FT /id="PRO_0000314746"
FT DOMAIN 26..193
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ SEQUENCE 212 AA; 23913 MW; 627C3CC311FD93C1 CRC64;
MDLPPLSLDQ LSAVITAGPT PTDLYTSLSA YEEQACLLSA TDPSEKDLLL EFYTAFFFSH
LLTDQICEAR ALTRRIPREI SRLDAMQTCS LLLRAVWQSK HTEIYKILRE LPWPGRSQPL
VQRYESYFQE KTLVEMSNSY ETIRIAAAAT YLGLDPAAVE GDIIEKFTAC GWKWDSEKQL
LHPKPVVTAP PKDDSLQNEL SRVMALISNQ GS
