ID   CSN8_RAT                Reviewed;         209 AA.
AC   Q6P4Z9;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=COP9 signalosome complex subunit 8;
DE            Short=SGN8;
DE            Short=Signalosome subunit 8;
DE   AltName: Full=COP9 homolog;
DE   AltName: Full=JAB1-containing signalosome subunit 8;
GN   Name=Cops8; Synonyms=Csn8;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a complex
CC       involved in various cellular and developmental processes. The CSN
CC       complex is an essential regulator of the ubiquitin (Ubl) conjugation
CC       pathway by mediating the deneddylation of the cullin subunits of SCF-
CC       type E3 ligase complexes, leading to decrease the Ubl ligase activity
CC       of SCF-type complexes such as SCF, CSA or DDB2. The complex is also
CC       involved in phosphorylation of p53/TP53, c-jun/JUN,
CC       IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association
CC       with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN
CC       promotes and protects degradation by the Ubl system, respectively (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the CSN complex, composed of COPS1/GPS1, COPS2,
CC       COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9.
CC       In the complex, it probably interacts directly with COPS3, COPS4 and
CC       COPS7 (COPS7A or COPS7B). {ECO:0000250|UniProtKB:Q99627}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSN8 family. {ECO:0000305}.
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DR   EMBL; BC063182; AAH63182.1; -; mRNA.
DR   RefSeq; NP_001013245.1; NM_001013227.2.
DR   AlphaFoldDB; Q6P4Z9; -.
DR   SMR; Q6P4Z9; -.
DR   IntAct; Q6P4Z9; 1.
DR   STRING; 10116.ENSRNOP00000026581; -.
DR   iPTMnet; Q6P4Z9; -.
DR   PhosphoSitePlus; Q6P4Z9; -.
DR   jPOST; Q6P4Z9; -.
DR   PaxDb; Q6P4Z9; -.
DR   PRIDE; Q6P4Z9; -.
DR   DNASU; 363283; -.
DR   Ensembl; ENSRNOT00000106176; ENSRNOP00000095164; ENSRNOG00000019635.
DR   GeneID; 363283; -.
DR   KEGG; rno:363283; -.
DR   UCSC; RGD:1311404; rat.
DR   CTD; 10920; -.
DR   RGD; 1311404; Cops8.
DR   eggNOG; KOG4414; Eukaryota.
DR   GeneTree; ENSGT00390000000977; -.
DR   HOGENOM; CLU_098091_1_1_1; -.
DR   InParanoid; Q6P4Z9; -.
DR   OMA; DFSTRMV; -.
DR   OrthoDB; 1577916at2759; -.
DR   PhylomeDB; Q6P4Z9; -.
DR   Reactome; R-RNO-5696394; DNA Damage Recognition in GG-NER.
DR   Reactome; R-RNO-6781823; Formation of TC-NER Pre-Incision Complex.
DR   Reactome; R-RNO-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR   Reactome; R-RNO-8951664; Neddylation.
DR   PRO; PR:Q6P4Z9; -.
DR   Proteomes; UP000002494; Chromosome 9.
DR   Bgee; ENSRNOG00000019635; Expressed in quadriceps femoris and 19 other tissues.
DR   Genevisible; Q6P4Z9; RN.
DR   GO; GO:0008180; C:COP9 signalosome; ISO:RGD.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:RGD.
DR   GO; GO:0007250; P:activation of NF-kappaB-inducing kinase activity; ISO:RGD.
DR   GO; GO:0010387; P:COP9 signalosome assembly; IEA:InterPro.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:RGD.
DR   GO; GO:0000338; P:protein deneddylation; ISO:RGD.
DR   GO; GO:0006468; P:protein phosphorylation; ISO:RGD.
DR   InterPro; IPR033205; COP9_CSN8.
DR   InterPro; IPR033464; CSN8_PSD8_EIF3K.
DR   InterPro; IPR000717; PCI_dom.
DR   PANTHER; PTHR13339; PTHR13339; 1.
DR   Pfam; PF10075; CSN8_PSD8_EIF3K; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Signalosome.
FT   CHAIN           1..209
FT                   /note="COP9 signalosome complex subunit 8"
FT                   /id="PRO_0000121010"
FT   DOMAIN          8..179
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   MOD_RES         175
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q99627"
SQ   SEQUENCE   209 AA;  23236 MW;  DB80E9C47BFAD5B8 CRC64;
     MPVAVMADNA FSFRKLLDQC ENQELEAPGG IATPPVYGQL LALYLLQNDM NNARYLWKRI
     PPAIKSANSE LGGIWSVGQR IWQRDFPGIY TTINAHQWSE TVQPIMEALR DATRRRAFAL
     VSQAYTSIIA DDFAAFVGLP VEEAVKGVLE QGWQADSTTR MVLPRKPAPG ALDVSLNRFI
     PLSEPAPVPP IPNEQQLARL TDYVAFLEN