ID   CSN8_XENLA              Reviewed;         195 AA.
AC   Q6GQA6;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 2.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=COP9 signalosome complex subunit 8;
DE            Short=Signalosome subunit 8;
GN   Name=csn8;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a complex
CC       involved in various cellular and developmental processes. The CSN
CC       complex is an essential regulator of the ubiquitin (Ubl) conjugation
CC       pathway by mediating the deneddylation of the cullin subunits of E3
CC       ligase complexes, leading to modify the Ubl ligase activity (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the CSN complex, probably composed of cops1,
CC       cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
CC       {ECO:0000250|UniProtKB:Q99627}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSN8 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH72840.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC072840; AAH72840.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001085491.1; NM_001092022.1.
DR   AlphaFoldDB; Q6GQA6; -.
DR   SMR; Q6GQA6; -.
DR   MaxQB; Q6GQA6; -.
DR   DNASU; 443917; -.
DR   GeneID; 443917; -.
DR   KEGG; xla:443917; -.
DR   CTD; 443917; -.
DR   Xenbase; XB-GENE-6078417; cops8.S.
DR   OMA; DAKLLWM; -.
DR   OrthoDB; 1577916at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10S.
DR   Bgee; 443917; Expressed in ovary and 19 other tissues.
DR   GO; GO:0008180; C:COP9 signalosome; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0010387; P:COP9 signalosome assembly; IEA:InterPro.
DR   GO; GO:0000338; P:protein deneddylation; IEA:InterPro.
DR   InterPro; IPR033205; COP9_CSN8.
DR   InterPro; IPR033464; CSN8_PSD8_EIF3K.
DR   InterPro; IPR000717; PCI_dom.
DR   PANTHER; PTHR13339; PTHR13339; 1.
DR   Pfam; PF10075; CSN8_PSD8_EIF3K; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..195
FT                   /note="COP9 signalosome complex subunit 8"
FT                   /id="PRO_0000121012"
FT   DOMAIN          10..183
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   195 AA;  21756 MW;  461D5F6E11685A2D CRC64;
     MKLSESVMAQ NSVSFQKLQE QCEEQELEAP GGIASPQVYN QLLALYLLHN DLNNARYLWK
     RIPSAIKSSH SELGGIWEVG QKIWQRDFPG IYTSISAYQW SENIQQIMEA VRDATQQRAF
     GLVSQAYTSI SADDFAAFVG LPVEEAVKGV LEQGWQADSA TGMVMPKKPD SAPLSLIPNE
     QQLARLTDYV AFLEN