ID   CSN8_XENTR              Reviewed;         193 AA.
AC   Q6P637; Q28F35;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=COP9 signalosome complex subunit 8;
DE            Short=Signalosome subunit 8;
GN   Name=csn8; ORFNames=TGas005p10.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a complex
CC       involved in various cellular and developmental processes. The CSN
CC       complex is an essential regulator of the ubiquitin (Ubl) conjugation
CC       pathway by mediating the deneddylation of the cullin subunits of E3
CC       ligase complexes, leading to modify the Ubl ligase activity (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the CSN complex, probably composed of cops1,
CC       cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
CC       {ECO:0000250|UniProtKB:Q99627}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSN8 family. {ECO:0000305}.
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DR   EMBL; CR762193; CAJ81631.1; -; mRNA.
DR   EMBL; BC062497; AAH62497.1; -; mRNA.
DR   RefSeq; NP_989106.1; NM_203775.1.
DR   RefSeq; XP_012825713.1; XM_012970259.2.
DR   AlphaFoldDB; Q6P637; -.
DR   SMR; Q6P637; -.
DR   PaxDb; Q6P637; -.
DR   DNASU; 394711; -.
DR   GeneID; 394711; -.
DR   KEGG; xtr:394711; -.
DR   CTD; 10920; -.
DR   Xenbase; XB-GENE-5956805; cops8.
DR   eggNOG; KOG4414; Eukaryota.
DR   HOGENOM; CLU_098091_1_1_1; -.
DR   InParanoid; Q6P637; -.
DR   OrthoDB; 1577916at2759; -.
DR   Reactome; R-XTR-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR   Reactome; R-XTR-8951664; Neddylation.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0008180; C:COP9 signalosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0010387; P:COP9 signalosome assembly; IEA:InterPro.
DR   GO; GO:0000338; P:protein deneddylation; IEA:InterPro.
DR   InterPro; IPR033205; COP9_CSN8.
DR   InterPro; IPR033464; CSN8_PSD8_EIF3K.
DR   InterPro; IPR000717; PCI_dom.
DR   PANTHER; PTHR13339; PTHR13339; 1.
DR   Pfam; PF10075; CSN8_PSD8_EIF3K; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..193
FT                   /note="COP9 signalosome complex subunit 8"
FT                   /id="PRO_0000121013"
FT   DOMAIN          8..181
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   193 AA;  21552 MW;  53B3AFE30BB08F08 CRC64;
     MPVAVMAQNP VSFQRLQEQC EEQELEAPGG IANPQVYSQL LALYLLHNDM NNARYLWKRI
     PPAIKSAHSE LGGIWEVGQK IWQRDFPGIY TSISACQWSE AIQPVMEAVR DATRRRAFGL
     VSQAYTSISA DDFAAFVGLS VEEAVKGVIE QGWQADLATR MVMPKKPDSA PLSLIPNEQQ
     LARLTDYVAF LEN