ID   CSN9_BOVIN              Reviewed;          57 AA.
AC   Q32PD7;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=COP9 signalosome complex subunit 9 {ECO:0000305};
GN   Name=COPS9 {ECO:0000250|UniProtKB:Q8WXC6}; Synonyms=MYEOV2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a complex
CC       involved in various cellular and developmental processes. The CSN
CC       complex is an essential regulator of the ubiquitin (Ubl) conjugation
CC       pathway by mediating the deneddylation of the cullin subunits of SCF-
CC       type E3 ligase complexes, leading to decrease the Ubl ligase activity
CC       of SCF-type complexes such as SCF, CSA or DDB2. The complex is also
CC       involved in phosphorylation of p53/TP53, c-jun/JUN,
CC       IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association
CC       with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN
CC       promotes and protects degradation by the Ubl system, respectively.
CC       Plays a role in cell proliferation. {ECO:0000250|UniProtKB:Q8WXC6}.
CC   -!- SUBUNIT: Component of the CSN complex, composed of COPS1/GPS1, COPS2,
CC       COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9.
CC       In the complex, it interacts directly with COPS3, COPS5 and COPS6.
CC       {ECO:0000250|UniProtKB:Q8WXC6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8WXC6}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8WXC6}. Nucleus, nucleoplasm
CC       {ECO:0000250|UniProtKB:Q8WXC6}. Note=Excluded from the nucleolus.
CC       Recruited to the nucleoplasm and chromatin following DNA damage
CC       induction. {ECO:0000250|UniProtKB:Q8WXC6}.
CC   -!- DOMAIN: The Phe/Asp-rich domain at the C-terminus is necessary for its
CC       incorporation into the CSN complex. {ECO:0000250|UniProtKB:Q8WXC6}.
CC   -!- SIMILARITY: Belongs to the CSN9 family. {ECO:0000305}.
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DR   EMBL; BC108156; AAI08157.1; -; mRNA.
DR   RefSeq; NP_001181980.1; NM_001195051.1.
DR   AlphaFoldDB; Q32PD7; -.
DR   STRING; 9913.ENSBTAP00000014490; -.
DR   PaxDb; Q32PD7; -.
DR   PRIDE; Q32PD7; -.
DR   Ensembl; ENSBTAT00000014490; ENSBTAP00000014490; ENSBTAG00000010910.
DR   GeneID; 617407; -.
DR   KEGG; bta:617407; -.
DR   CTD; 150678; -.
DR   VEuPathDB; HostDB:ENSBTAG00000010910; -.
DR   VGNC; VGNC:54910; COPS9.
DR   eggNOG; ENOG502S7KZ; Eukaryota.
DR   GeneTree; ENSGT00390000000076; -.
DR   HOGENOM; CLU_191079_0_0_1; -.
DR   InParanoid; Q32PD7; -.
DR   OMA; SNDKHVH; -.
DR   OrthoDB; 1635275at2759; -.
DR   TreeFam; TF323869; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000010910; Expressed in oocyte and 104 other tissues.
DR   GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR   GO; GO:0008180; C:COP9 signalosome; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0034644; P:cellular response to UV; ISS:UniProtKB.
DR   GO; GO:2000435; P:negative regulation of protein neddylation; IBA:GO_Central.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR   InterPro; IPR029391; CSN9_metazoa.
DR   PANTHER; PTHR28562; PTHR28562; 1.
DR   Pfam; PF15004; MYEOV2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Signalosome.
FT   CHAIN           1..57
FT                   /note="COP9 signalosome complex subunit 9"
FT                   /id="PRO_0000332923"
FT   MOD_RES         26
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8WXC6"
SQ   SEQUENCE   57 AA;  6211 MW;  8306DAFBF3DC610C CRC64;
     MKPAVDEMFP EGAGPYVDLD EAGGSTGLLM DLAANEKAVH ADFFNDFEDL FDDDDIQ