ID   CSN9_DANRE              Reviewed;          57 AA.
AC   Q6P6E6;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 2.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=COP9 signalosome complex subunit 9 {ECO:0000305};
GN   Name=cops9 {ECO:0000250|UniProtKB:Q8WXC6}; Synonyms=myeov2;
GN   ORFNames=zgc:77808;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a complex
CC       involved in various cellular and developmental processes. The CSN
CC       complex is an essential regulator of the ubiquitin (Ubl) conjugation
CC       pathway by mediating the deneddylation of the cullin subunits of SCF-
CC       type E3 ligase complexes, leading to decrease the Ubl ligase activity.
CC       May play a role in cell proliferation. {ECO:0000250|UniProtKB:Q8WXC6}.
CC   -!- SUBUNIT: Component of the CSN complex, probably composed of cops1,
CC       cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
CC       {ECO:0000250|UniProtKB:Q8WXC6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8WXC6}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8WXC6}. Nucleus, nucleoplasm
CC       {ECO:0000250|UniProtKB:Q8WXC6}.
CC   -!- SIMILARITY: Belongs to the CSN9 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH62283.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC062283; AAH62283.1; ALT_INIT; mRNA.
DR   RefSeq; NP_957141.2; NM_200847.2.
DR   AlphaFoldDB; Q6P6E6; -.
DR   STRING; 7955.ENSDARP00000106916; -.
DR   PaxDb; Q6P6E6; -.
DR   PRIDE; Q6P6E6; -.
DR   Ensembl; ENSDART00000130696; ENSDARP00000106916; ENSDARG00000045296.
DR   GeneID; 393820; -.
DR   KEGG; dre:393820; -.
DR   CTD; 150678; -.
DR   ZFIN; ZDB-GENE-040426-1883; cops9.
DR   eggNOG; ENOG502S7KZ; Eukaryota.
DR   GeneTree; ENSGT00390000000076; -.
DR   HOGENOM; CLU_191079_0_0_1; -.
DR   InParanoid; Q6P6E6; -.
DR   OMA; SNDKHVH; -.
DR   OrthoDB; 1635275at2759; -.
DR   PhylomeDB; Q6P6E6; -.
DR   TreeFam; TF323869; -.
DR   PRO; PR:Q6P6E6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 24.
DR   Bgee; ENSDARG00000045296; Expressed in testis and 29 other tissues.
DR   GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR   GO; GO:0008180; C:COP9 signalosome; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0034644; P:cellular response to UV; ISS:UniProtKB.
DR   GO; GO:2000435; P:negative regulation of protein neddylation; IBA:GO_Central.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR   InterPro; IPR029391; CSN9_metazoa.
DR   PANTHER; PTHR28562; PTHR28562; 1.
DR   Pfam; PF15004; MYEOV2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..57
FT                   /note="COP9 signalosome complex subunit 9"
FT                   /id="PRO_0000332926"
SQ   SEQUENCE   57 AA;  6213 MW;  DC422AFBF3DC610B CRC64;
     MKPAVDEMFP EGAGPYVDLD EAGGSSGLLM DLAANEKAVH SDFFNDFEDL FDDDDIQ