ID   CSN9_XENLA              Reviewed;          57 AA.
AC   A1L3P1;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 32.
DE   RecName: Full=COP9 signalosome complex subunit 9 {ECO:0000305};
GN   Name=cops9 {ECO:0000250|UniProtKB:Q8WXC6}; Synonyms=myeov2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a complex
CC       involved in various cellular and developmental processes. The CSN
CC       complex is an essential regulator of the ubiquitin (Ubl) conjugation
CC       pathway by mediating the deneddylation of the cullin subunits of SCF-
CC       type E3 ligase complexes, leading to decrease the Ubl ligase activity.
CC       May play a role in cell proliferation. {ECO:0000250|UniProtKB:Q8WXC6}.
CC   -!- SUBUNIT: Component of the CSN complex, probably composed of cops1,
CC       cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
CC       {ECO:0000250|UniProtKB:Q8WXC6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8WXC6}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8WXC6}. Nucleus, nucleoplasm
CC       {ECO:0000250|UniProtKB:Q8WXC6}.
CC   -!- SIMILARITY: Belongs to the CSN9 family. {ECO:0000305}.
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DR   EMBL; BC130217; AAI30218.1; -; mRNA.
DR   RefSeq; NP_001165255.1; NM_001171784.1.
DR   AlphaFoldDB; A1L3P1; -.
DR   DNASU; 100037056; -.
DR   GeneID; 100037056; -.
DR   KEGG; xla:100037056; -.
DR   CTD; 100037056; -.
DR   Xenbase; XB-GENE-6255530; cops9.S.
DR   OrthoDB; 1635275at2759; -.
DR   Proteomes; UP000186698; Chromosome 5S.
DR   Bgee; 100037056; Expressed in internal ear and 19 other tissues.
DR   GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR   GO; GO:0008180; C:COP9 signalosome; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0034644; P:cellular response to UV; ISS:UniProtKB.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR   InterPro; IPR029391; CSN9_metazoa.
DR   PANTHER; PTHR28562; PTHR28562; 1.
DR   Pfam; PF15004; MYEOV2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..57
FT                   /note="COP9 signalosome complex subunit 9"
FT                   /id="PRO_0000332927"
SQ   SEQUENCE   57 AA;  6212 MW;  9843CAFA43DC6C66 CRC64;
     MKPAVDEMFP EGAGPYVDLD EAGGSSGLLM DLAADEKAVH ADFFNDFEDL FDDEDIQ