CSN9_YEAST
ID CSN9_YEAST Reviewed; 162 AA.
AC Q03981; D6VSG1;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=COP9 signalosome complex subunit 9;
GN Name=CSN9; OrderedLocusNames=YDR179C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP FUNCTION OF THE COP9 SIGNALOSOME COMPLEX.
RX PubMed=12186635; DOI=10.1186/1471-2156-3-15;
RA Wee S., Hetfeld B., Dubiel W., Wolf D.A.;
RT "Conservation of the COP9/signalosome in budding yeast.";
RL BMC Genet. 3:15-15(2002).
RN [5]
RP INTERACTION WITH CSN12 AND CSI1, IDENTIFICATION IN THE COP9 SIGNALOSOME
RP COMPLEX, AND FUNCTION OF THE COP9 SIGNALOSOME COMPLEX.
RX PubMed=12446563; DOI=10.1093/embo-reports/kvf235;
RA Maytal-Kivity V., Piran R., Pick E., Hofmann K., Glickman M.H.;
RT "COP9 signalosome components play a role in the mating pheromone response
RT of S. cerevisiae.";
RL EMBO Rep. 3:1215-1221(2002).
RN [6]
RP INTERACTION WITH RRI1/CSN5, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=11805826; DOI=10.1038/415141a;
RA Gavin A.-C., Boesche M., Krause R., Grandi P., Marzioch M., Bauer A.,
RA Schultz J., Rick J.M., Michon A.-M., Cruciat C.-M., Remor M., Hoefert C.,
RA Schelder M., Brajenovic M., Ruffner H., Merino A., Klein K., Hudak M.,
RA Dickson D., Rudi T., Gnau V., Bauch A., Bastuck S., Huhse B., Leutwein C.,
RA Heurtier M.-A., Copley R.R., Edelmann A., Querfurth E., Rybin V.,
RA Drewes G., Raida M., Bouwmeester T., Bork P., Seraphin B., Kuster B.,
RA Neubauer G., Superti-Furga G.;
RT "Functional organization of the yeast proteome by systematic analysis of
RT protein complexes.";
RL Nature 415:141-147(2002).
RN [7]
RP INTERACTION WITH CSN12; CSI1 AND RPN5, AND IDENTIFICATION IN THE COP9
RP SIGNALOSOME COMPLEX.
RX PubMed=12672462; DOI=10.1016/s1357-2725(02)00378-3;
RA Maytal-Kivity V., Pick E., Piran R., Hofmann K., Glickman M.H.;
RT "The COP9 signalosome-like complex in S. cerevisiae and links to other PCI
RT complexes.";
RL Int. J. Biochem. Cell Biol. 35:706-715(2003).
RN [8]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [9]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: Component of the COP9 signalosome (CSN) complex that acts as
CC a regulator of the ubiquitin (Ubl) conjugation pathway by mediating the
CC deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein
CC ligase complexes. The CSN complex is involved in the regulation of the
CC mating pheromone response. {ECO:0000269|PubMed:12186635,
CC ECO:0000269|PubMed:12446563}.
CC -!- SUBUNIT: Component of a COP9 signalosome-like (CSN) complex, composed
CC of at least RRI1/CSN5, CSN9, RRI2/CSN10, PCI8/CSN11, CSN12 and CSI1. In
CC the complex, it probably interacts directly with CSN12 and CSI1.
CC Interacts also with RPN5. {ECO:0000269|PubMed:11805826,
CC ECO:0000269|PubMed:12446563, ECO:0000269|PubMed:12672462}.
CC -!- INTERACTION:
CC Q03981; Q04368: CSI1; NbExp=5; IntAct=EBI-33535, EBI-28044;
CC Q03981; Q12250: RPN5; NbExp=5; IntAct=EBI-33535, EBI-15935;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:14562095}. Nucleus
CC {ECO:0000305|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 358 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; Z46727; CAA86684.1; -; Genomic_DNA.
DR EMBL; AY557666; AAS55992.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA12021.1; -; Genomic_DNA.
DR PIR; S49775; S49775.
DR RefSeq; NP_010464.1; NM_001180486.1.
DR AlphaFoldDB; Q03981; -.
DR SMR; Q03981; -.
DR BioGRID; 32232; 137.
DR ComplexPortal; CPX-1894; COP9 signalosome complex.
DR DIP; DIP-1580N; -.
DR IntAct; Q03981; 11.
DR MINT; Q03981; -.
DR STRING; 4932.YDR179C; -.
DR MaxQB; Q03981; -.
DR PaxDb; Q03981; -.
DR PRIDE; Q03981; -.
DR EnsemblFungi; YDR179C_mRNA; YDR179C; YDR179C.
DR GeneID; 851759; -.
DR KEGG; sce:YDR179C; -.
DR SGD; S000002586; CSN9.
DR VEuPathDB; FungiDB:YDR179C; -.
DR eggNOG; ENOG502S4AD; Eukaryota.
DR HOGENOM; CLU_138722_0_0_1; -.
DR InParanoid; Q03981; -.
DR OMA; FDCRDVY; -.
DR BioCyc; YEAST:G3O-29767-MON; -.
DR PRO; PR:Q03981; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; Q03981; protein.
DR GO; GO:0008180; C:COP9 signalosome; IDA:SGD.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IC:ComplexPortal.
DR GO; GO:0000754; P:adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion; IMP:SGD.
DR GO; GO:0000338; P:protein deneddylation; IMP:SGD.
DR InterPro; IPR016806; Csn9_fungi.
DR PIRSF; PIRSF022632; UCP022632; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT CHAIN 1..162
FT /note="COP9 signalosome complex subunit 9"
FT /id="PRO_0000121020"
FT DOMAIN 6..118
FT /note="PCI"
SQ SEQUENCE 162 AA; 19476 MW; 686C8BE7BFBDD802 CRC64;
MVMREETIKS LEDPYKYHYK EEWLNTKDPD EQQLFEIFAF GNIKDLPENI ILTSLMRSKL
EKLTLVTLSE IYNELSYELI KEECQIEDDG IIESHLIQLQ NIFKAEMDSV SKSMKFSRRF
DCRDVYCHEK ELTIIKNPRV TKEYLVQNLR SWETKLKQNI LE
