ID   CSOR_MYCUA              Reviewed;         117 AA.
AC   A0PLB8;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 2.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Copper-sensing transcriptional repressor CsoR;
DE   AltName: Full=Copper-sensitive operon repressor;
GN   Name=csoR; OrderedLocusNames=MUL_0425;
OS   Mycobacterium ulcerans (strain Agy99).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=362242;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Agy99;
RX   PubMed=17210928; DOI=10.1101/gr.5942807;
RA   Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T.,
RA   Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J.,
RA   Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M.,
RA   Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T.;
RT   "Reductive evolution and niche adaptation inferred from the genome of
RT   Mycobacterium ulcerans, the causative agent of Buruli ulcer.";
RL   Genome Res. 17:192-200(2007).
CC   -!- FUNCTION: Copper-sensitive repressor that has a key role in copper
CC       homeostasis. It is part of the cso operon involved in the cellular
CC       response to increasing concentrations of copper inside the bacterium,
CC       which can be highly toxic. In the presence of copper, CsoR fully
CC       dissociates from the promoter in the cso operon, leading to the
CC       transcription of its genes. Binds to a GC-rich pseudopallindromic
CC       sequence, 5'-GTAGCCCACCCCCAGTGGGGTGGGA-3', in the cso promoter region
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: This protein has an antiparallel four-helix bundle architecture
CC       that represents a novel DNA-binding fold. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CsoR family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABL03137.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000325; ABL03137.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_071498077.1; NC_008611.1.
DR   AlphaFoldDB; A0PLB8; -.
DR   SMR; A0PLB8; -.
DR   STRING; 362242.MUL_0425; -.
DR   EnsemblBacteria; ABL03137; ABL03137; MUL_0425.
DR   KEGG; mul:MUL_0425; -.
DR   eggNOG; COG1937; Bacteria.
DR   HOGENOM; CLU_130332_1_1_11; -.
DR   Proteomes; UP000000765; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProt.
DR   Gene3D; 1.20.58.1000; -; 1.
DR   InterPro; IPR003735; Metal_Tscrpt_repr.
DR   InterPro; IPR038390; Metal_Tscrpt_repr_sf.
DR   PANTHER; PTHR33677; PTHR33677; 1.
DR   Pfam; PF02583; Trns_repr_metal; 1.
PE   3: Inferred from homology;
KW   Copper; Cytoplasm; DNA-binding; Metal-binding; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..117
FT                   /note="Copper-sensing transcriptional repressor CsoR"
FT                   /id="PRO_0000295583"
FT   BINDING         36
FT                   /ligand="Cu cation"
FT                   /ligand_id="ChEBI:CHEBI:23378"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT                   /evidence="ECO:0000250"
FT   BINDING         61
FT                   /ligand="Cu cation"
FT                   /ligand_id="ChEBI:CHEBI:23378"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /evidence="ECO:0000250"
FT   BINDING         65
FT                   /ligand="Cu cation"
FT                   /ligand_id="ChEBI:CHEBI:23378"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   117 AA;  12534 MW;  C5D15E5C382EE745 CRC64;
     MSHELTDKKR AALNRLKTAR GHLDGIIRML ESDAYCVDVM KQLSAVQSSL ERANRVMLHN
     HLETCFSAAV LDGRGQAAID ELIDAVKFTP ALTGPQAQLG GAVVCKPPGD QPAQSPA