ID   CSP1_STRR6              Reviewed;          41 AA.
AC   P60243; Q54712;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-JAN-2004, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Competence-stimulating peptide type 1;
DE            Short=CSP-1;
DE   Flags: Precursor;
GN   Name=comC1; Synonyms=comC; OrderedLocusNames=spr2043;
OS   Streptococcus pneumoniae (strain ATCC BAA-255 / R6).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=171101;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=R6x;
RX   PubMed=9157240; DOI=10.1046/j.1365-2958.1997.2481617.x;
RA   Cheng Q., Campbell E.A., Naughton A.M., Johnson S., Masure H.R.;
RT   "The com locus controls genetic transformation in Streptococcus
RT   pneumoniae.";
RL   Mol. Microbiol. 23:683-692(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC BAA-255 / R6;
RX   PubMed=10322016; DOI=10.1128/jb.181.10.3144-3154.1999;
RA   Whatmore A.M.;
RT   "Genetic diversity of the streptococcal competence (com) locus.";
RL   J. Bacteriol. 181:3144-3154(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-255 / R6;
RX   PubMed=11544234; DOI=10.1128/jb.183.19.5709-5717.2001;
RA   Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S.,
RA   DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C.,
RA   Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., LeBlanc D.J.,
RA   Lee L.N., Lefkowitz E.J., Lu J., Matsushima P., McAhren S.M., McHenney M.,
RA   McLeaster K., Mundy C.W., Nicas T.I., Norris F.H., O'Gara M., Peery R.B.,
RA   Robertson G.T., Rockey P., Sun P.-M., Winkler M.E., Yang Y.,
RA   Young-Bellido M., Zhao G., Zook C.A., Baltz R.H., Jaskunas S.R.,
RA   Rosteck P.R. Jr., Skatrud P.L., Glass J.I.;
RT   "Genome of the bacterium Streptococcus pneumoniae strain R6.";
RL   J. Bacteriol. 183:5709-5717(2001).
CC   -!- FUNCTION: Acts as a pheromone, induces cells to develop competence for
CC       genetic transformation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the ComC family. {ECO:0000305}.
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DR   EMBL; U76218; AAC44895.1; -; Genomic_DNA.
DR   EMBL; AJ240787; CAB39514.1; -; Genomic_DNA.
DR   EMBL; AE007317; AAL00845.1; -; Genomic_DNA.
DR   PIR; H98126; H98126.
DR   RefSeq; NP_359634.1; NC_003098.1.
DR   RefSeq; WP_000799689.1; NC_003098.1.
DR   PDB; 2A1C; NMR; -; A=25-41.
DR   PDBsum; 2A1C; -.
DR   AlphaFoldDB; P60243; -.
DR   BMRB; P60243; -.
DR   SMR; P60243; -.
DR   STRING; 171101.spr2043; -.
DR   EnsemblBacteria; AAL00845; AAL00845; spr2043.
DR   GeneID; 60232604; -.
DR   GeneID; 66807309; -.
DR   KEGG; spr:spr2043; -.
DR   PATRIC; fig|171101.6.peg.2209; -.
DR   eggNOG; ENOG5032ASE; Bacteria.
DR   HOGENOM; CLU_216496_0_0_9; -.
DR   EvolutionaryTrace; P60243; -.
DR   Proteomes; UP000000586; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005186; F:pheromone activity; IEA:UniProtKB-KW.
DR   GO; GO:0030420; P:establishment of competence for transformation; IEA:UniProtKB-KW.
DR   InterPro; IPR004288; Competence_ComC.
DR   Pfam; PF03047; ComC; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Competence; Pheromone; Reference proteome; Secreted.
FT   PROPEP          1..24
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000005883"
FT   PEPTIDE         25..41
FT                   /note="Competence-stimulating peptide type 1"
FT                   /id="PRO_0000005884"
FT   STRAND          27..29
FT                   /evidence="ECO:0007829|PDB:2A1C"
FT   HELIX           30..36
FT                   /evidence="ECO:0007829|PDB:2A1C"
SQ   SEQUENCE   41 AA;  4971 MW;  1448B414E980E86A CRC64;
     MKNTVKLEQF VALKEKDLQK IKGGEMRLSK FFRDFILQRK K