ID   CSP2_STRM6              Reviewed;          40 AA.
AC   O33666; D3HBR9;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Competence-stimulating peptide;
DE            Short=CSP;
DE   Flags: Precursor;
GN   Name=comC; OrderedLocusNames=smi_2085;
OS   Streptococcus mitis (strain B6).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=365659;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9352904; DOI=10.1128/jb.179.21.6589-6594.1997;
RA   Haevarstein L.S., Hakenbeck R., Gaustad P.;
RT   "Natural competence in the genus Streptococcus: evidence that streptococci
RT   can change pherotype by interspecies recombinational exchanges.";
RL   J. Bacteriol. 179:6589-6594(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B6;
RX   PubMed=20195536; DOI=10.1371/journal.pone.0009426;
RA   Denapaite D., Bruckner R., Nuhn M., Reichmann P., Henrich B., Maurer P.,
RA   Schahle Y., Selbmann P., Zimmermann W., Wambutt R., Hakenbeck R.;
RT   "The genome of Streptococcus mitis B6--what is a commensal?";
RL   PLoS ONE 5:E9426-E9426(2010).
CC   -!- FUNCTION: Acts as a pheromone, induces cells to develop competence for
CC       genetic transformation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the ComC family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ000865; CAA04344.1; -; Genomic_DNA.
DR   EMBL; FN568063; CBJ23319.1; -; Genomic_DNA.
DR   RefSeq; WP_000799698.1; NC_013853.1.
DR   RefSeq; YP_003447179.1; NC_013853.1.
DR   AlphaFoldDB; O33666; -.
DR   STRING; 365659.smi_2085; -.
DR   EnsemblBacteria; CBJ23319; CBJ23319; smi_2085.
DR   KEGG; smb:smi_2085; -.
DR   PATRIC; fig|365659.3.peg.2096; -.
DR   eggNOG; ENOG50303JE; Bacteria.
DR   HOGENOM; CLU_216496_0_0_9; -.
DR   Proteomes; UP000008563; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005186; F:pheromone activity; IEA:UniProtKB-KW.
DR   GO; GO:0030420; P:establishment of competence for transformation; IEA:UniProtKB-KW.
DR   InterPro; IPR004288; Competence_ComC.
DR   Pfam; PF03047; ComC; 1.
PE   3: Inferred from homology;
KW   Competence; Pheromone; Secreted.
FT   PROPEP          1..24
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000005871"
FT   PEPTIDE         25..40
FT                   /note="Competence-stimulating peptide"
FT                   /id="PRO_0000005872"
SQ   SEQUENCE   40 AA;  4749 MW;  9F4F5FC7AE4EE922 CRC64;
     MKNTVKLEQF VALKEKELQK IKGGEMRKPD GALFNLFRRR