ID   CSPA_ECOL6              Reviewed;          70 AA.
AC   P0A9Y0; P15277; P37410; Q54170;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Cold shock protein CspA;
DE            Short=CSP-A;
DE   AltName: Full=7.4 kDa cold shock protein;
DE   AltName: Full=CS7.4;
GN   Name=cspA; OrderedLocusNames=c4377;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Binds to and stimulates the transcription of the CCAAT-
CC       containing, cold-shock-inducible promoters of the H-NS and GyrA
CC       proteins. Binds also to the inverted repeat 5'-ATTGG-3' (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- INDUCTION: In response to low temperature. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE014075; AAN82813.1; -; Genomic_DNA.
DR   RefSeq; WP_000014594.1; NC_004431.1.
DR   AlphaFoldDB; P0A9Y0; -.
DR   BMRB; P0A9Y0; -.
DR   SMR; P0A9Y0; -.
DR   EnsemblBacteria; AAN82813; AAN82813; c4377.
DR   GeneID; 64293021; -.
DR   GeneID; 67517040; -.
DR   KEGG; ecc:c4377; -.
DR   eggNOG; COG1278; Bacteria.
DR   HOGENOM; CLU_117621_2_1_6; -.
DR   OMA; GPCANKV; -.
DR   BioCyc; ECOL199310:C4377-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0005829; C:cytosol; IEA:UniProt.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   CDD; cd04458; CSP_CDS; 1.
DR   Gene3D; 2.40.50.140; -; 1.
DR   InterPro; IPR012156; Cold_shock_CspA.
DR   InterPro; IPR011129; CSD.
DR   InterPro; IPR019844; CSD_1.
DR   InterPro; IPR002059; CSP_DNA-bd.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   Pfam; PF00313; CSD; 1.
DR   PIRSF; PIRSF002599; Cold_shock_A; 1.
DR   PRINTS; PR00050; COLDSHOCK.
DR   SMART; SM00357; CSP; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   PROSITE; PS00352; CSD_1; 1.
DR   PROSITE; PS51857; CSD_2; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Stress response; Transcription;
KW   Transcription regulation.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..70
FT                   /note="Cold shock protein CspA"
FT                   /id="PRO_0000100234"
FT   DOMAIN          7..67
FT                   /note="CSD"
SQ   SEQUENCE   70 AA;  7403 MW;  CED47F00BF18A49B CRC64;
     MSGKMTGIVK WFNADKGFGF ITPDDGSKDV FVHFSAIQND GYKSLDEGQK VSFTIESGAK
     GPAAGNVTSL