CSPA_SALTY
ID CSPA_SALTY Reviewed; 70 AA.
AC P0A9Y2; P15277; P37410; Q54170;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Cold shock protein CspA;
DE Short=CSP-A;
DE AltName: Full=7.4 kDa cold shock protein;
DE AltName: Full=CS7.4;
GN Name=cspA; OrderedLocusNames=STM3649;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 19585;
RX PubMed=10696873; DOI=10.1023/a:1002055719798;
RA Horton A.J., Hak K.M., Steffan R.J., Foster J.W., Bej A.K.;
RT "Adaptive response to cold temperatures and characterization of cspA in
RT Salmonella typhimurium LT2.";
RL Antonie Van Leeuwenhoek 77:13-20(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=3027;
RA Tamura N., Yu D.T.Y.;
RL Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 15-60.
RC STRAIN=LT2;
RX PubMed=9439003; DOI=10.1038/sj.jim.2900463;
RA Francis K.P., Stewart G.S.A.B.;
RT "Detection and speciation of bacteria through PCR using universal major
RT cold-shock protein primer oligomers.";
RL J. Ind. Microbiol. Biotechnol. 19:286-293(1997).
CC -!- FUNCTION: Binds to and stimulates the transcription of the CCAAT-
CC containing, cold-shock-inducible promoters of the H-NS and GyrA
CC proteins. Binds also to the inverted repeat 5'-ATTGG-3' (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- INDUCTION: In response to low temperature. {ECO:0000250}.
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DR EMBL; L23115; AAB66357.1; -; Genomic_DNA.
DR EMBL; AF052579; AAC06036.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL22509.1; -; Genomic_DNA.
DR EMBL; U60048; AAC80252.1; -; Genomic_DNA.
DR RefSeq; NP_462550.1; NC_003197.2.
DR RefSeq; WP_000014594.1; NC_003197.2.
DR AlphaFoldDB; P0A9Y2; -.
DR BMRB; P0A9Y2; -.
DR SMR; P0A9Y2; -.
DR STRING; 99287.STM3649; -.
DR PaxDb; P0A9Y2; -.
DR EnsemblBacteria; AAL22509; AAL22509; STM3649.
DR GeneID; 1255173; -.
DR GeneID; 64293021; -.
DR GeneID; 67517040; -.
DR KEGG; stm:STM3649; -.
DR PATRIC; fig|99287.12.peg.3860; -.
DR HOGENOM; CLU_117621_2_1_6; -.
DR OMA; GPCANKV; -.
DR PhylomeDB; P0A9Y2; -.
DR BioCyc; SENT99287:STM3649-MON; -.
DR PRO; PR:P0A9Y2; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0001072; F:transcription antitermination factor activity, RNA binding; IBA:GO_Central.
DR GO; GO:0060567; P:negative regulation of DNA-templated transcription, termination; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR CDD; cd04458; CSP_CDS; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR InterPro; IPR012156; Cold_shock_CspA.
DR InterPro; IPR011129; CSD.
DR InterPro; IPR019844; CSD_1.
DR InterPro; IPR002059; CSP_DNA-bd.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR Pfam; PF00313; CSD; 1.
DR PIRSF; PIRSF002599; Cold_shock_A; 1.
DR PRINTS; PR00050; COLDSHOCK.
DR SMART; SM00357; CSP; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR PROSITE; PS00352; CSD_1; 1.
DR PROSITE; PS51857; CSD_2; 1.
PE 3: Inferred from homology;
KW Activator; Cytoplasm; DNA-binding; Reference proteome; Stress response;
KW Transcription; Transcription regulation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..70
FT /note="Cold shock protein CspA"
FT /id="PRO_0000100238"
FT DOMAIN 7..67
FT /note="CSD"
FT CONFLICT 65
FT /note="G -> A (in Ref. 1; AAB66357)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 70 AA; 7403 MW; CED47F00BF18A49B CRC64;
MSGKMTGIVK WFNADKGFGF ITPDDGSKDV FVHFSAIQND GYKSLDEGQK VSFTIESGAK
GPAAGNVTSL
