CSPA_SHIFL
ID CSPA_SHIFL Reviewed; 70 AA.
AC P0A9Y4; P15277; P37410; Q54170;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Cold shock protein CspA;
DE Short=CSP-A;
DE AltName: Full=7.4 kDa cold shock protein;
DE AltName: Full=CS7.4;
GN Name=cspA; OrderedLocusNames=SF3589, S4179;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 15-60.
RC STRAIN=NCTC 0002;
RX PubMed=9439003; DOI=10.1038/sj.jim.2900463;
RA Francis K.P., Stewart G.S.A.B.;
RT "Detection and speciation of bacteria through PCR using universal major
RT cold-shock protein primer oligomers.";
RL J. Ind. Microbiol. Biotechnol. 19:286-293(1997).
CC -!- FUNCTION: Binds to and stimulates the transcription of the CCAAT-
CC containing, cold-shock-inducible promoters of the H-NS and GyrA
CC proteins. Binds also to the inverted repeat 5'-ATTGG-3' (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- INDUCTION: In response to low temperature. {ECO:0000250}.
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DR EMBL; AE005674; AAN45040.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP19147.1; -; Genomic_DNA.
DR EMBL; U60037; AAC80241.1; -; Genomic_DNA.
DR RefSeq; NP_709333.1; NC_004337.2.
DR RefSeq; WP_000014594.1; NZ_WPGW01000020.1.
DR AlphaFoldDB; P0A9Y4; -.
DR SMR; P0A9Y4; -.
DR STRING; 198214.SF3589; -.
DR PRIDE; P0A9Y4; -.
DR EnsemblBacteria; AAN45040; AAN45040; SF3589.
DR EnsemblBacteria; AAP19147; AAP19147; S4179.
DR GeneID; 1026303; -.
DR GeneID; 64293021; -.
DR GeneID; 67517040; -.
DR KEGG; sfl:SF3589; -.
DR KEGG; sfx:S4179; -.
DR PATRIC; fig|198214.7.peg.4236; -.
DR HOGENOM; CLU_117621_2_1_6; -.
DR OMA; GPCANKV; -.
DR OrthoDB; 2034748at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR CDD; cd04458; CSP_CDS; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR InterPro; IPR012156; Cold_shock_CspA.
DR InterPro; IPR011129; CSD.
DR InterPro; IPR019844; CSD_1.
DR InterPro; IPR002059; CSP_DNA-bd.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR Pfam; PF00313; CSD; 1.
DR PIRSF; PIRSF002599; Cold_shock_A; 1.
DR PRINTS; PR00050; COLDSHOCK.
DR SMART; SM00357; CSP; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR PROSITE; PS00352; CSD_1; 1.
DR PROSITE; PS51857; CSD_2; 1.
PE 3: Inferred from homology;
KW Activator; Cytoplasm; DNA-binding; Reference proteome; Stress response;
KW Transcription; Transcription regulation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..70
FT /note="Cold shock protein CspA"
FT /id="PRO_0000100239"
FT DOMAIN 7..67
FT /note="CSD"
SQ SEQUENCE 70 AA; 7403 MW; CED47F00BF18A49B CRC64;
MSGKMTGIVK WFNADKGFGF ITPDDGSKDV FVHFSAIQND GYKSLDEGQK VSFTIESGAK
GPAAGNVTSL
