ID   CSPA_STRP1              Reviewed;          67 AA.
AC   P0C0F1; P0A359; Q48W92; Q54974;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Major cold shock protein;
GN   Name=cspA; Synonyms=csp, cspC; OrderedLocusNames=SPy_2077, M5005_Spy1765;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA   Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of serotype
RT   M1 group A Streptococcus involved multiple horizontal gene transfer
RT   events.";
RL   J. Infect. Dis. 192:771-782(2005).
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- INDUCTION: In response to low temperature. {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAZ52383.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE004092; AAK34731.1; -; Genomic_DNA.
DR   EMBL; CP000017; AAZ52383.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_270010.1; NC_002737.2.
DR   AlphaFoldDB; P0C0F1; -.
DR   SMR; P0C0F1; -.
DR   STRING; 1314.HKU360_01879; -.
DR   PaxDb; P0C0F1; -.
DR   EnsemblBacteria; AAK34731; AAK34731; SPy_2077.
DR   KEGG; spy:SPy_2077; -.
DR   KEGG; spz:M5005_Spy1765; -.
DR   PATRIC; fig|160490.10.peg.1800; -.
DR   HOGENOM; CLU_117621_6_1_9; -.
DR   OMA; FEIQDGH; -.
DR   Proteomes; UP000000750; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   CDD; cd04458; CSP_CDS; 1.
DR   Gene3D; 2.40.50.140; -; 1.
DR   InterPro; IPR012156; Cold_shock_CspA.
DR   InterPro; IPR011129; CSD.
DR   InterPro; IPR019844; CSD_1.
DR   InterPro; IPR002059; CSP_DNA-bd.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   Pfam; PF00313; CSD; 1.
DR   PIRSF; PIRSF002599; Cold_shock_A; 1.
DR   PRINTS; PR00050; COLDSHOCK.
DR   SMART; SM00357; CSP; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   PROSITE; PS00352; CSD_1; 1.
DR   PROSITE; PS51857; CSD_2; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Reference proteome; Stress response;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..67
FT                   /note="Major cold shock protein"
FT                   /id="PRO_0000100334"
FT   DOMAIN          4..63
FT                   /note="CSD"
SQ   SEQUENCE   67 AA;  7322 MW;  A8D499734D82C3F0 CRC64;
     MAQGTVKWFN AEKGFGFIST ENGQDVFAHF SAIQTNGFKT LEEGQKVAFD VEEGQRGPQA
     VNITKLA