ID   CSPA_STRP6              Reviewed;          67 AA.
AC   Q5X9L4;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 2.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Major cold shock protein;
GN   Name=cspA; Synonyms=csp, cspC; OrderedLocusNames=M6_Spy1764;
OS   Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=286636;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-946 / MGAS10394;
RX   PubMed=15272401; DOI=10.1086/422697;
RA   Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E.,
RA   Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.;
RT   "Progress toward characterization of the group A Streptococcus metagenome:
RT   complete genome sequence of a macrolide-resistant serotype M6 strain.";
RL   J. Infect. Dis. 190:727-738(2004).
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- INDUCTION: In response to low temperature. {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAT87899.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000003; AAT87899.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_021340196.1; NC_006086.1.
DR   AlphaFoldDB; Q5X9L4; -.
DR   SMR; Q5X9L4; -.
DR   EnsemblBacteria; AAT87899; AAT87899; M6_Spy1764.
DR   KEGG; spa:M6_Spy1764; -.
DR   HOGENOM; CLU_117621_6_1_9; -.
DR   Proteomes; UP000001167; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   CDD; cd04458; CSP_CDS; 1.
DR   Gene3D; 2.40.50.140; -; 1.
DR   InterPro; IPR012156; Cold_shock_CspA.
DR   InterPro; IPR011129; CSD.
DR   InterPro; IPR019844; CSD_1.
DR   InterPro; IPR002059; CSP_DNA-bd.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   Pfam; PF00313; CSD; 1.
DR   PIRSF; PIRSF002599; Cold_shock_A; 1.
DR   PRINTS; PR00050; COLDSHOCK.
DR   SMART; SM00357; CSP; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   PROSITE; PS00352; CSD_1; 1.
DR   PROSITE; PS51857; CSD_2; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..67
FT                   /note="Major cold shock protein"
FT                   /id="PRO_0000100336"
FT   DOMAIN          4..63
FT                   /note="CSD"
SQ   SEQUENCE   67 AA;  7295 MW;  06DA69734D82C3EC CRC64;
     MAQGTVKWFN AEKGFGFIST ENGQDVFAHF SAIQTSGFKT LEEGQKVAFD VEEGQRGPQA
     VNITKLA