CSPA_STRP8
ID CSPA_STRP8 Reviewed; 67 AA.
AC P0A361; Q54974;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Major cold shock protein;
GN Name=cspA; Synonyms=csp, cspC; OrderedLocusNames=spyM18_2136;
OS Streptococcus pyogenes serotype M18 (strain MGAS8232).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=186103;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGAS8232;
RX PubMed=11917108; DOI=10.1073/pnas.062526099;
RA Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S.,
RA Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D.,
RA Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A.,
RA Veasy L.G., Musser J.M.;
RT "Genome sequence and comparative microarray analysis of serotype M18 group
RT A Streptococcus strains associated with acute rheumatic fever outbreaks.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002).
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- INDUCTION: In response to low temperature. {ECO:0000250}.
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DR EMBL; AE009949; AAL98586.1; -; Genomic_DNA.
DR RefSeq; WP_002991299.1; NC_003485.1.
DR AlphaFoldDB; P0A361; -.
DR SMR; P0A361; -.
DR GeneID; 57853431; -.
DR KEGG; spm:spyM18_2136; -.
DR HOGENOM; CLU_117621_6_1_9; -.
DR OMA; FEIQDGH; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR CDD; cd04458; CSP_CDS; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR InterPro; IPR012156; Cold_shock_CspA.
DR InterPro; IPR011129; CSD.
DR InterPro; IPR019844; CSD_1.
DR InterPro; IPR002059; CSP_DNA-bd.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR Pfam; PF00313; CSD; 1.
DR PIRSF; PIRSF002599; Cold_shock_A; 1.
DR PRINTS; PR00050; COLDSHOCK.
DR SMART; SM00357; CSP; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR PROSITE; PS00352; CSD_1; 1.
DR PROSITE; PS51857; CSD_2; 1.
PE 3: Inferred from homology;
KW Activator; Cytoplasm; DNA-binding; Stress response; Transcription;
KW Transcription regulation.
FT CHAIN 1..67
FT /note="Major cold shock protein"
FT /id="PRO_0000100337"
FT DOMAIN 4..63
FT /note="CSD"
SQ SEQUENCE 67 AA; 7322 MW; A8D499734D82C3F0 CRC64;
MAQGTVKWFN AEKGFGFIST ENGQDVFAHF SAIQTNGFKT LEEGQKVAFD VEEGQRGPQA
VNITKLA