ID   CSPA_STRPQ              Reviewed;          67 AA.
AC   P0DA49; P0A360; Q54974;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Major cold shock protein;
GN   Name=cspA; Synonyms=csp, cspC; OrderedLocusNames=SPs1766;
OS   Streptococcus pyogenes serotype M3 (strain SSI-1).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=193567;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SSI-1;
RX   PubMed=12799345; DOI=10.1101/gr.1096703;
RA   Nakagawa I., Kurokawa K., Yamashita A., Nakata M., Tomiyasu Y.,
RA   Okahashi N., Kawabata S., Yamazaki K., Shiba T., Yasunaga T., Hayashi H.,
RA   Hattori M., Hamada S.;
RT   "Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-
RT   scale genomic rearrangement in invasive strains and new insights into phage
RT   evolution.";
RL   Genome Res. 13:1042-1055(2003).
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- INDUCTION: In response to low temperature. {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC64861.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BA000034; BAC64861.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_002991299.1; NC_004606.1.
DR   AlphaFoldDB; P0DA49; -.
DR   SMR; P0DA49; -.
DR   GeneID; 57853431; -.
DR   KEGG; sps:SPs1766; -.
DR   HOGENOM; CLU_117621_6_1_9; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   CDD; cd04458; CSP_CDS; 1.
DR   Gene3D; 2.40.50.140; -; 1.
DR   InterPro; IPR012156; Cold_shock_CspA.
DR   InterPro; IPR011129; CSD.
DR   InterPro; IPR019844; CSD_1.
DR   InterPro; IPR002059; CSP_DNA-bd.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   Pfam; PF00313; CSD; 1.
DR   PIRSF; PIRSF002599; Cold_shock_A; 1.
DR   PRINTS; PR00050; COLDSHOCK.
DR   SMART; SM00357; CSP; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   PROSITE; PS00352; CSD_1; 1.
DR   PROSITE; PS51857; CSD_2; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..67
FT                   /note="Major cold shock protein"
FT                   /id="PRO_0000411312"
FT   DOMAIN          4..63
FT                   /note="CSD"
SQ   SEQUENCE   67 AA;  7322 MW;  A8D499734D82C3F0 CRC64;
     MAQGTVKWFN AEKGFGFIST ENGQDVFAHF SAIQTNGFKT LEEGQKVAFD VEEGQRGPQA
     VNITKLA