ID   CSPL1_VITVI             Reviewed;         204 AA.
AC   A7QC16; A5BI77; D7U8E7;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-APR-2009, sequence version 2.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=CASP-like protein 1B2;
DE            Short=VvCASPL1B2;
GN   OrderedLocusNames=VIT_10s0092g00220;
GN   ORFNames=GSVIVT00035198001, GSVIVT01037957001, VIT_00037957001,
GN   VITISV_004162, Vv10s0092g00220;
OS   Vitis vinifera (Grape).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; Vitales; Vitaceae; Viteae; Vitis.
OX   NCBI_TaxID=29760;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Pinot noir / PN40024;
RX   PubMed=17721507; DOI=10.1038/nature06148;
RA   Jaillon O., Aury J.-M., Noel B., Policriti A., Clepet C., Casagrande A.,
RA   Choisne N., Aubourg S., Vitulo N., Jubin C., Vezzi A., Legeai F.,
RA   Hugueney P., Dasilva C., Horner D., Mica E., Jublot D., Poulain J.,
RA   Bruyere C., Billault A., Segurens B., Gouyvenoux M., Ugarte E.,
RA   Cattonaro F., Anthouard V., Vico V., Del Fabbro C., Alaux M.,
RA   Di Gaspero G., Dumas V., Felice N., Paillard S., Juman I., Moroldo M.,
RA   Scalabrin S., Canaguier A., Le Clainche I., Malacrida G., Durand E.,
RA   Pesole G., Laucou V., Chatelet P., Merdinoglu D., Delledonne M.,
RA   Pezzotti M., Lecharny A., Scarpelli C., Artiguenave F., Pe M.E., Valle G.,
RA   Morgante M., Caboche M., Adam-Blondon A.-F., Weissenbach J., Quetier F.,
RA   Wincker P.;
RT   "The grapevine genome sequence suggests ancestral hexaploidization in major
RT   angiosperm phyla.";
RL   Nature 449:463-467(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Pinot noir;
RX   PubMed=18094749; DOI=10.1371/journal.pone.0001326;
RA   Velasco R., Zharkikh A., Troggio M., Cartwright D.A., Cestaro A., Pruss D.,
RA   Pindo M., FitzGerald L.M., Vezzulli S., Reid J., Malacarne G., Iliev D.,
RA   Coppola G., Wardell B., Micheletti D., Macalma T., Facci M., Mitchell J.T.,
RA   Perazzolli M., Eldredge G., Gatto P., Oyzerski R., Moretto M., Gutin N.,
RA   Stefanini M., Chen Y., Segala C., Davenport C., Dematte L., Mraz A.,
RA   Battilana J., Stormo K., Costa F., Tao Q., Si-Ammour A., Harkins T.,
RA   Lackey A., Perbost C., Taillon B., Stella A., Solovyev V., Fawcett J.A.,
RA   Sterck L., Vandepoele K., Grando S.M., Toppo S., Moser C., Lanchbury J.,
RA   Bogden R., Skolnick M., Sgaramella V., Bhatnagar S.K., Fontana P.,
RA   Gutin A., Van de Peer Y., Salamini F., Viola R.;
RT   "A high quality draft consensus sequence of the genome of a heterozygous
RT   grapevine variety.";
RL   PLoS ONE 2:E1326-E1326(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Cabernet Sauvignon;
RA   Reid K.E., Liao N., Peng F., Schlosser J., Kirkpatrick R., Shukin R.,
RA   Barber S., Holt R., Siddiqui A., Jones S., Marra M., Bowen P., Bohlmann J.,
RA   Martinez Zapater J.M., Lund S.T.;
RT   "Expressed sequence tags from grapevine (Vitis vinifera cv. Cabernet
RT   Sauvignon).";
RL   Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=24920445; DOI=10.1104/pp.114.239137;
RA   Roppolo D., Boeckmann B., Pfister A., Boutet E., Rubio M.C.,
RA   Denervaud-Tendon V., Vermeer J.E., Gheyselinck J., Xenarios I., Geldner N.;
RT   "Functional and evolutionary analysis of the CASPARIAN STRIP MEMBRANE
RT   DOMAIN PROTEIN family.";
RL   Plant Physiol. 165:1709-1722(2014).
CC   -!- SUBUNIT: Homodimer and heterodimers. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Casparian strip membrane proteins (CASP)
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FN596741; CBI39011.3; -; Genomic_DNA.
DR   EMBL; FN597030; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AM460343; CAN76914.1; -; Genomic_DNA.
DR   EMBL; EC925758; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; XP_002276662.1; XM_002276626.4.
DR   AlphaFoldDB; A7QC16; -.
DR   STRING; 29760.VIT_10s0092g00220.t01; -.
DR   GeneID; 100247713; -.
DR   KEGG; vvi:100247713; -.
DR   eggNOG; ENOG502RYH6; Eukaryota.
DR   HOGENOM; CLU_066104_1_0_1; -.
DR   InParanoid; A7QC16; -.
DR   OrthoDB; 1282932at2759; -.
DR   Proteomes; UP000009183; Chromosome 10.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IBA:GO_Central.
DR   InterPro; IPR006459; CASP/CASPL.
DR   InterPro; IPR006702; CASP_dom.
DR   Pfam; PF04535; DUF588; 1.
DR   TIGRFAMs; TIGR01569; A_tha_TIGR01569; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..204
FT                   /note="CASP-like protein 1B2"
FT                   /id="PRO_0000370306"
FT   TOPO_DOM        1..28
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..80
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        102..114
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        136..168
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        190..204
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        12
FT                   /note="V -> A (in Ref. 3; EC925758)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        20
FT                   /note="S -> G (in Ref. 3; EC925758)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        181
FT                   /note="F -> L (in Ref. 1; CBI39011)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   204 AA;  21613 MW;  D866E9EA6ECF9C00 CRC64;
     MASKGEEKPE LVGSKQGIVS VTKAKHDQIV LVLRVVAFLA TASATIVMGL NQETKTLLVG
     TIGTTPIRAT LKAKFQHTPA FVFFVVANGL ASVYNLVMLG VDVFGRKLDC KGLRLVIISI
     LDMVIVAVVA AGASSAAFMA ELGKNGNSHA KWNKICDKFE SFCHQGGGAL IPSFIALLLL
     FLISAISIIT LHNQKLTSPH ATTP