ID   CSPLA_PHYPA             Reviewed;         214 AA.
AC   A9S1T8;
DT   09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=CASP-like protein UU5;
DE            Short=PpCASPLUU5;
GN   ORFNames=PHYPADRAFT_73452;
OS   Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Bryophyta;
OC   Bryophytina; Bryopsida; Funariidae; Funariales; Funariaceae; Physcomitrium.
OX   NCBI_TaxID=3218;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Gransden 2004;
RX   PubMed=18079367; DOI=10.1126/science.1150646;
RA   Rensing S.A., Lang D., Zimmer A.D., Terry A., Salamov A., Shapiro H.,
RA   Nishiyama T., Perroud P.-F., Lindquist E.A., Kamisugi Y., Tanahashi T.,
RA   Sakakibara K., Fujita T., Oishi K., Shin-I T., Kuroki Y., Toyoda A.,
RA   Suzuki Y., Hashimoto S.-I., Yamaguchi K., Sugano S., Kohara Y.,
RA   Fujiyama A., Anterola A., Aoki S., Ashton N., Barbazuk W.B., Barker E.,
RA   Bennetzen J.L., Blankenship R., Cho S.H., Dutcher S.K., Estelle M.,
RA   Fawcett J.A., Gundlach H., Hanada K., Heyl A., Hicks K.A., Hughes J.,
RA   Lohr M., Mayer K., Melkozernov A., Murata T., Nelson D.R., Pils B.,
RA   Prigge M., Reiss B., Renner T., Rombauts S., Rushton P.J., Sanderfoot A.,
RA   Schween G., Shiu S.-H., Stueber K., Theodoulou F.L., Tu H., Van de Peer Y.,
RA   Verrier P.J., Waters E., Wood A., Yang L., Cove D., Cuming A.C., Hasebe M.,
RA   Lucas S., Mishler B.D., Reski R., Grigoriev I.V., Quatrano R.S.,
RA   Boore J.L.;
RT   "The Physcomitrella genome reveals evolutionary insights into the conquest
RT   of land by plants.";
RL   Science 319:64-69(2008).
RN   [2]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=24920445; DOI=10.1104/pp.114.239137;
RA   Roppolo D., Boeckmann B., Pfister A., Boutet E., Rubio M.C.,
RA   Denervaud-Tendon V., Vermeer J.E., Gheyselinck J., Xenarios I., Geldner N.;
RT   "Functional and evolutionary analysis of the CASPARIAN STRIP MEMBRANE
RT   DOMAIN PROTEIN family.";
RL   Plant Physiol. 165:1709-1722(2014).
CC   -!- SUBUNIT: Homodimer and heterodimers. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Casparian strip membrane proteins (CASP)
CC       family. {ECO:0000305}.
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DR   EMBL; DS544931; EDQ74799.1; -; Genomic_DNA.
DR   RefSeq; XP_001760408.1; XM_001760356.1.
DR   AlphaFoldDB; A9S1T8; -.
DR   SMR; A9S1T8; -.
DR   EnsemblPlants; Pp3c7_9280V3.1; Pp3c7_9280V3.1; Pp3c7_9280.
DR   EnsemblPlants; Pp3c7_9280V3.2; Pp3c7_9280V3.2; Pp3c7_9280.
DR   EnsemblPlants; Pp3c7_9280V3.3; Pp3c7_9280V3.3; Pp3c7_9280.
DR   Gramene; Pp3c7_9280V3.1; Pp3c7_9280V3.1; Pp3c7_9280.
DR   Gramene; Pp3c7_9280V3.2; Pp3c7_9280V3.2; Pp3c7_9280.
DR   Gramene; Pp3c7_9280V3.3; Pp3c7_9280V3.3; Pp3c7_9280.
DR   eggNOG; ENOG502SF1Y; Eukaryota.
DR   HOGENOM; CLU_1290852_0_0_1; -.
DR   InParanoid; A9S1T8; -.
DR   OMA; NINHMSA; -.
DR   OrthoDB; 1448506at2759; -.
DR   Proteomes; UP000006727; Chromosome 7.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006702; CASP_dom.
DR   Pfam; PF04535; DUF588; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..214
FT                   /note="CASP-like protein UU5"
FT                   /id="PRO_0000391545"
FT   TOPO_DOM        1..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        79..99
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..138
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        160..193
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   214 AA;  22201 MW;  3E87FCC92EA07184 CRC64;
     MSTVAQDSAP GGGKIQDAME QGAPGASSAA VVPEGGHYTQ TPSPAFQAVK KNINHMSAFS
     LGLRVAEFVL SVIAFSLMAS ADQNGAVYST FTSYSFVLAV NVLVVFYTIG QIIMSVLLLV
     SGSTPKKIYL FITFGCDQLS AFLLMAAGAA GASVALIINR GGVTDAYGNG CIDGKITSFC
     SHAQASVAFT FLSFFCMVIS SLLGVYSLAP YLIL