ID   CSPLA_VITVI             Reviewed;         205 AA.
AC   A7QBZ2; D7TAG9;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=CASP-like protein 2A1;
DE            Short=VvCASPL2A1;
GN   OrderedLocusNames=VIT_01s0010g01870;
GN   ORFNames=GSVIVT00035166001, GSVIVT01010256001, VIT_00010256001,
GN   Vv01s0010g01870;
OS   Vitis vinifera (Grape).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; Vitales; Vitaceae; Viteae; Vitis.
OX   NCBI_TaxID=29760;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Pinot noir / PN40024;
RX   PubMed=17721507; DOI=10.1038/nature06148;
RA   Jaillon O., Aury J.-M., Noel B., Policriti A., Clepet C., Casagrande A.,
RA   Choisne N., Aubourg S., Vitulo N., Jubin C., Vezzi A., Legeai F.,
RA   Hugueney P., Dasilva C., Horner D., Mica E., Jublot D., Poulain J.,
RA   Bruyere C., Billault A., Segurens B., Gouyvenoux M., Ugarte E.,
RA   Cattonaro F., Anthouard V., Vico V., Del Fabbro C., Alaux M.,
RA   Di Gaspero G., Dumas V., Felice N., Paillard S., Juman I., Moroldo M.,
RA   Scalabrin S., Canaguier A., Le Clainche I., Malacrida G., Durand E.,
RA   Pesole G., Laucou V., Chatelet P., Merdinoglu D., Delledonne M.,
RA   Pezzotti M., Lecharny A., Scarpelli C., Artiguenave F., Pe M.E., Valle G.,
RA   Morgante M., Caboche M., Adam-Blondon A.-F., Weissenbach J., Quetier F.,
RA   Wincker P.;
RT   "The grapevine genome sequence suggests ancestral hexaploidization in major
RT   angiosperm phyla.";
RL   Nature 449:463-467(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Cabernet Sauvignon; TISSUE=Seed;
RA   Reid K.E., Liao N., Peng F., Schlosser J., Kirkpatrick R., Shukin R.,
RA   Barber S., Holt R., Siddiqui A., Jones S., Marra M., Bowen P., Bohlmann J.,
RA   Martinez Zapater J.M., Lund S.T.;
RT   "Expressed sequence tags from grapevine (Vitis vinifera cv. Cabernet
RT   Sauvignon).";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=24920445; DOI=10.1104/pp.114.239137;
RA   Roppolo D., Boeckmann B., Pfister A., Boutet E., Rubio M.C.,
RA   Denervaud-Tendon V., Vermeer J.E., Gheyselinck J., Xenarios I., Geldner N.;
RT   "Functional and evolutionary analysis of the CASPARIAN STRIP MEMBRANE
RT   DOMAIN PROTEIN family.";
RL   Plant Physiol. 165:1709-1722(2014).
CC   -!- SUBUNIT: Homodimer and heterodimers. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Casparian strip membrane proteins (CASP)
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CBI27492.3; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; FN595754; CBI27492.3; ALT_INIT; Genomic_DNA.
DR   EMBL; FN597015; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; EC963598; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; XP_002275339.1; XM_002275303.4.
DR   AlphaFoldDB; A7QBZ2; -.
DR   STRING; 29760.VIT_01s0010g01870.t01; -.
DR   EnsemblPlants; Vitvi01g01460_t001; Vitvi01g01460_P001; Vitvi01g01460.
DR   GeneID; 100249479; -.
DR   Gramene; Vitvi01g01460_t001; Vitvi01g01460_P001; Vitvi01g01460.
DR   KEGG; vvi:100249479; -.
DR   eggNOG; ENOG502S0J7; Eukaryota.
DR   HOGENOM; CLU_066104_2_3_1; -.
DR   InParanoid; A7QBZ2; -.
DR   OrthoDB; 1252134at2759; -.
DR   Proteomes; UP000009183; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IBA:GO_Central.
DR   InterPro; IPR006459; CASP/CASPL.
DR   InterPro; IPR006702; CASP_dom.
DR   Pfam; PF04535; DUF588; 1.
DR   TIGRFAMs; TIGR01569; A_tha_TIGR01569; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..205
FT                   /note="CASP-like protein 2A1"
FT                   /id="PRO_0000370312"
FT   TOPO_DOM        1..35
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        57..77
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        99..106
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        128..157
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        179..205
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   205 AA;  21968 MW;  DDE728EB71057D09 CRC64;
     MMGDKGEKEC ATASSPIELG CGEGDESGNK SSMRTVETLL RLVPVALCTV SLVVMLKNSQ
     TNDFGSLSYS DLGAFRYLVH ANGICAGYSL LSAIFTAMPR PPTMSRAWTF FLLDQVLTYL
     ILAAGAVSTE VVYLAYKGDE AVTWSDACSS FGGFCQKTTA SISITFVTVL CYAVLSLISS
     YKLFSKYDAP ICFNGKGIEI AAFHS