CSPLC_ARATH
ID CSPLC_ARATH Reviewed; 178 AA.
AC Q8GWD5; O80640;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=CASP-like protein 4D1;
DE Short=AtCASPL4D1;
GN OrderedLocusNames=At2g39530; ORFNames=F12L6.19;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION, GENE FAMILY,
RP AND NOMENCLATURE.
RX PubMed=24920445; DOI=10.1104/pp.114.239137;
RA Roppolo D., Boeckmann B., Pfister A., Boutet E., Rubio M.C.,
RA Denervaud-Tendon V., Vermeer J.E., Gheyselinck J., Xenarios I., Geldner N.;
RT "Functional and evolutionary analysis of the CASPARIAN STRIP MEMBRANE
RT DOMAIN PROTEIN family.";
RL Plant Physiol. 165:1709-1722(2014).
CC -!- SUBUNIT: Homodimer and heterodimers. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24920445};
CC Multi-pass membrane protein {ECO:0000269|PubMed:24920445}.
CC -!- TISSUE SPECIFICITY: Expressed in the root epidermis.
CC {ECO:0000269|PubMed:24920445}.
CC -!- DEVELOPMENTAL STAGE: In the root epidermis, expressed transiently in
CC the root maturation zone. {ECO:0000269|PubMed:24920445}.
CC -!- SIMILARITY: Belongs to the Casparian strip membrane proteins (CASP)
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC27844.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC004218; AAC27844.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC09691.1; -; Genomic_DNA.
DR EMBL; AK118915; BAC43498.1; -; mRNA.
DR EMBL; BT005644; AAO64064.1; -; mRNA.
DR PIR; T00563; T00563.
DR RefSeq; NP_181485.2; NM_129511.3.
DR AlphaFoldDB; Q8GWD5; -.
DR BioGRID; 3876; 8.
DR IntAct; Q8GWD5; 8.
DR STRING; 3702.AT2G39530.1; -.
DR PaxDb; Q8GWD5; -.
DR PRIDE; Q8GWD5; -.
DR ProteomicsDB; 222706; -.
DR EnsemblPlants; AT2G39530.1; AT2G39530.1; AT2G39530.
DR GeneID; 818538; -.
DR Gramene; AT2G39530.1; AT2G39530.1; AT2G39530.
DR KEGG; ath:AT2G39530; -.
DR Araport; AT2G39530; -.
DR TAIR; locus:2039702; AT2G39530.
DR eggNOG; ENOG502S98H; Eukaryota.
DR HOGENOM; CLU_115129_0_0_1; -.
DR InParanoid; Q8GWD5; -.
DR OMA; CTNTVDV; -.
DR OrthoDB; 1520625at2759; -.
DR PhylomeDB; Q8GWD5; -.
DR PRO; PR:Q8GWD5; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8GWD5; baseline and differential.
DR Genevisible; Q8GWD5; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IBA:GO_Central.
DR InterPro; IPR006702; CASP_dom.
DR Pfam; PF04535; DUF588; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9SQU2"
FT CHAIN 2..178
FT /note="CASP-like protein 4D1"
FT /id="PRO_0000308664"
FT TOPO_DOM 2..14
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 36..60
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..97
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..149
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..178
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q9SQU2"
SQ SEQUENCE 178 AA; 19204 MW; 30D22E30DAEEEFB2 CRC64;
MAPPPPAPPS VTLRTVLLLL RVLTAAFLLI TVVLISTNTV TLEISSTSIK LPFNDVYAYR
YMLSAAVIGL VYAVVQLFLT ISQFATGKTH PLTYQFDFYG DKVISYLLAT GSAAGFGVSK
DLKDTYIALI EFDSTDPVDK FFSKGYASAS LLLFAFVSLA VLSVFSSLAL SKRPVPVS
