ID   CSPLC_PHYPA             Reviewed;         353 AA.
AC   A9RJH1;
DT   09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=CASP-like protein UU7;
DE            Short=PpCASPLUU7;
GN   ORFNames=PHYPADRAFT_66946;
OS   Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Bryophyta;
OC   Bryophytina; Bryopsida; Funariidae; Funariales; Funariaceae; Physcomitrium.
OX   NCBI_TaxID=3218;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Gransden 2004;
RX   PubMed=18079367; DOI=10.1126/science.1150646;
RA   Rensing S.A., Lang D., Zimmer A.D., Terry A., Salamov A., Shapiro H.,
RA   Nishiyama T., Perroud P.-F., Lindquist E.A., Kamisugi Y., Tanahashi T.,
RA   Sakakibara K., Fujita T., Oishi K., Shin-I T., Kuroki Y., Toyoda A.,
RA   Suzuki Y., Hashimoto S.-I., Yamaguchi K., Sugano S., Kohara Y.,
RA   Fujiyama A., Anterola A., Aoki S., Ashton N., Barbazuk W.B., Barker E.,
RA   Bennetzen J.L., Blankenship R., Cho S.H., Dutcher S.K., Estelle M.,
RA   Fawcett J.A., Gundlach H., Hanada K., Heyl A., Hicks K.A., Hughes J.,
RA   Lohr M., Mayer K., Melkozernov A., Murata T., Nelson D.R., Pils B.,
RA   Prigge M., Reiss B., Renner T., Rombauts S., Rushton P.J., Sanderfoot A.,
RA   Schween G., Shiu S.-H., Stueber K., Theodoulou F.L., Tu H., Van de Peer Y.,
RA   Verrier P.J., Waters E., Wood A., Yang L., Cove D., Cuming A.C., Hasebe M.,
RA   Lucas S., Mishler B.D., Reski R., Grigoriev I.V., Quatrano R.S.,
RA   Boore J.L.;
RT   "The Physcomitrella genome reveals evolutionary insights into the conquest
RT   of land by plants.";
RL   Science 319:64-69(2008).
RN   [2]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=24920445; DOI=10.1104/pp.114.239137;
RA   Roppolo D., Boeckmann B., Pfister A., Boutet E., Rubio M.C.,
RA   Denervaud-Tendon V., Vermeer J.E., Gheyselinck J., Xenarios I., Geldner N.;
RT   "Functional and evolutionary analysis of the CASPARIAN STRIP MEMBRANE
RT   DOMAIN PROTEIN family.";
RL   Plant Physiol. 165:1709-1722(2014).
CC   -!- SUBUNIT: Homodimer and heterodimers. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Casparian strip membrane proteins (CASP)
CC       family. {ECO:0000305}.
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DR   EMBL; DS544902; EDQ80832.1; -; Genomic_DNA.
DR   RefSeq; XP_001754382.1; XM_001754330.1.
DR   AlphaFoldDB; A9RJH1; -.
DR   SMR; A9RJH1; -.
DR   PRIDE; A9RJH1; -.
DR   EnsemblPlants; Pp3c4_19470V3.1; Pp3c4_19470V3.1; Pp3c4_19470.
DR   EnsemblPlants; Pp3c4_19470V3.2; Pp3c4_19470V3.2; Pp3c4_19470.
DR   EnsemblPlants; Pp3c4_19470V3.3; Pp3c4_19470V3.3; Pp3c4_19470.
DR   Gramene; Pp3c4_19470V3.1; Pp3c4_19470V3.1; Pp3c4_19470.
DR   Gramene; Pp3c4_19470V3.2; Pp3c4_19470V3.2; Pp3c4_19470.
DR   Gramene; Pp3c4_19470V3.3; Pp3c4_19470V3.3; Pp3c4_19470.
DR   HOGENOM; CLU_736486_0_0_1; -.
DR   InParanoid; A9RJH1; -.
DR   OrthoDB; 1520625at2759; -.
DR   Proteomes; UP000006727; Chromosome 4.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006459; CASP/CASPL.
DR   InterPro; IPR006702; CASP_dom.
DR   Pfam; PF04535; DUF588; 1.
DR   TIGRFAMs; TIGR01569; A_tha_TIGR01569; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..353
FT                   /note="CASP-like protein UU7"
FT                   /id="PRO_0000391557"
FT   TOPO_DOM        1..184
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        206..250
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        251..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        272..277
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        299..320
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        321..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        342..353
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          70..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..21
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   353 AA;  38728 MW;  9D33D7ED68E7CF31 CRC64;
     MGTVTDSKAE ADEHGEKTDG GVESIDAVQG HGNRLESPDL NNFKPNGKNV AYVSSKIRAG
     VKVDWPTDSI YHQGTADGPA GSEDGAQSHA KRVNASPGRI HIHRGASGGI LRGLSGGIHL
     PTLQSITFEM TRLPDDDAGL QMHFTETKEV ETLPETPRGS IRRAMVEVPS RKQSKLRKHL
     TPMGACSFGF RLSQIVLSLI SIVVMCSNSQ RMHTPEVDFG TLKFNHFQAY RYLIAVNVCV
     IFYSTLQFTQ LMYIVILGIS FIPSIVISTW TTYGFDQLFT YLLLSASTSA GTIANISYNG
     EMGVSLCSRF DLASFCARAD AAVTLSFFTF LVMFSSTALA VYRICVMMRE FHR