CSPLE_ARATH
ID CSPLE_ARATH Reviewed; 178 AA.
AC Q9LUL1;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=CASP-like protein 2A2;
DE Short=AtCASPL2A2;
GN OrderedLocusNames=At3g14380; ORFNames=MLN21.16;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
RN [4]
RP FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, AND ALTERNATIVE
RP SPLICING.
RX PubMed=22992509; DOI=10.1104/pp.112.205955;
RA Gonzalez-Carranza Z.H., Shahid A.A., Zhang L., Liu Y., Ninsuwan U.,
RA Roberts J.A.;
RT "A novel approach to dissect the abscission process in Arabidopsis.";
RL Plant Physiol. 160:1342-1356(2012).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=24920445; DOI=10.1104/pp.114.239137;
RA Roppolo D., Boeckmann B., Pfister A., Boutet E., Rubio M.C.,
RA Denervaud-Tendon V., Vermeer J.E., Gheyselinck J., Xenarios I., Geldner N.;
RT "Functional and evolutionary analysis of the CASPARIAN STRIP MEMBRANE
RT DOMAIN PROTEIN family.";
RL Plant Physiol. 165:1709-1722(2014).
CC -!- FUNCTION: Involved in floral organ shedding.
CC {ECO:0000269|PubMed:22992509}.
CC -!- SUBUNIT: Homodimer and heterodimers. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced.
CC {ECO:0000269|PubMed:22992509};
CC Name=1;
CC IsoId=Q9LUL1-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Mostly expressed in flowers and buds and, to a
CC lower extent, in roots and yellow siliques. Localized in the floral
CC organ abscission zone. {ECO:0000269|PubMed:22992509}.
CC -!- DISRUPTION PHENOTYPE: Delayed timing of petal abscission.
CC {ECO:0000269|PubMed:22992509}.
CC -!- SIMILARITY: Belongs to the Casparian strip membrane proteins (CASP)
CC family. {ECO:0000305}.
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DR EMBL; AB022220; BAB01043.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE75510.1; -; Genomic_DNA.
DR EMBL; BX825321; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_188055.1; NM_112296.3. [Q9LUL1-1]
DR AlphaFoldDB; Q9LUL1; -.
DR SMR; Q9LUL1; -.
DR STRING; 3702.AT3G14380.1; -.
DR iPTMnet; Q9LUL1; -.
DR PaxDb; Q9LUL1; -.
DR PRIDE; Q9LUL1; -.
DR ProteomicsDB; 222686; -. [Q9LUL1-1]
DR EnsemblPlants; AT3G14380.1; AT3G14380.1; AT3G14380. [Q9LUL1-1]
DR GeneID; 820659; -.
DR Gramene; AT3G14380.1; AT3G14380.1; AT3G14380. [Q9LUL1-1]
DR KEGG; ath:AT3G14380; -.
DR Araport; AT3G14380; -.
DR TAIR; locus:2091045; AT3G14380.
DR eggNOG; ENOG502S0J7; Eukaryota.
DR HOGENOM; CLU_066104_2_2_1; -.
DR InParanoid; Q9LUL1; -.
DR OMA; VIMIKNS; -.
DR OrthoDB; 1252134at2759; -.
DR PhylomeDB; Q9LUL1; -.
DR PRO; PR:Q9LUL1; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LUL1; baseline and differential.
DR Genevisible; Q9LUL1; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IBA:GO_Central.
DR GO; GO:0010227; P:floral organ abscission; IEP:TAIR.
DR InterPro; IPR006459; CASP/CASPL.
DR InterPro; IPR006702; CASP_dom.
DR Pfam; PF04535; DUF588; 1.
DR TIGRFAMs; TIGR01569; A_tha_TIGR01569; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..178
FT /note="CASP-like protein 2A2"
FT /id="PRO_0000308667"
FT TOPO_DOM 1..22
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 44..69
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..96
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 118..145
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 167..178
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 137
FT /note="D -> N (in Ref. 3; BX825321)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 178 AA; 19184 MW; A4D8CAC5E8CA7C07 CRC64;
MDKTDQTAID ESALVLNRTE KSAEAVLRVA SMALSITGLV IMIKNSISNE FGSVSYSNIG
AFMYLVSANG VCAAYSLLSA LAILALPCPI SKVQVRTLFL LDQVVTYVVL AAGAVSAETV
YLAYYGNIPI TWSSACDSYG SFCHNALISV VFTFVVSLLY MLLSLISSYR LFTRFEAP
