ID   CSPLF_MAIZE             Reviewed;         306 AA.
AC   B6TWJ1; B6TEL6;
DT   09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT   09-FEB-2010, sequence version 2.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=CASP-like protein 4A1;
DE            Short=ZmCASPL4A1;
DE   AltName: Full=UL36 tegument protein;
OS   Zea mays (Maize).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX   NCBI_TaxID=4577;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX   PubMed=18937034; DOI=10.1007/s11103-008-9415-4;
RA   Alexandrov N.N., Brover V.V., Freidin S., Troukhan M.E., Tatarinova T.V.,
RA   Zhang H., Swaller T.J., Lu Y.-P., Bouck J., Flavell R.B., Feldmann K.A.;
RT   "Insights into corn genes derived from large-scale cDNA sequencing.";
RL   Plant Mol. Biol. 69:179-194(2009).
RN   [2]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=24920445; DOI=10.1104/pp.114.239137;
RA   Roppolo D., Boeckmann B., Pfister A., Boutet E., Rubio M.C.,
RA   Denervaud-Tendon V., Vermeer J.E., Gheyselinck J., Xenarios I., Geldner N.;
RT   "Functional and evolutionary analysis of the CASPARIAN STRIP MEMBRANE
RT   DOMAIN PROTEIN family.";
RL   Plant Physiol. 165:1709-1722(2014).
CC   -!- SUBUNIT: Homodimer and heterodimers. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=B6TWJ1-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=B6TWJ1-2; Sequence=VSP_038731;
CC   -!- SIMILARITY: Belongs to the Casparian strip membrane proteins (CASP)
CC       family. {ECO:0000305}.
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DR   EMBL; EU963431; ACG35549.1; -; mRNA.
DR   EMBL; EU969356; ACG41474.1; -; mRNA.
DR   TCDB; 9.B.56.1.3; the bacterial disease resistance and oomycete disease susceptibility protein, pimp1 (pimp1) family.
DR   PRIDE; B6TWJ1; -.
DR   Proteomes; UP000007305; Unplaced.
DR   ExpressionAtlas; B6TWJ1; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006702; CASP_dom.
DR   Pfam; PF04535; DUF588; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..306
FT                   /note="CASP-like protein 4A1"
FT                   /id="PRO_0000391577"
FT   TOPO_DOM        1..158
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        180..201
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        223..242
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        261..277
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        299..306
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          1..142
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        95..132
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         55..199
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:18937034"
FT                   /id="VSP_038731"
FT   CONFLICT        306
FT                   /note="M -> I (in Ref. 1; ACG35549)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   306 AA;  32779 MW;  8E03BB8825729A63 CRC64;
     MALQAQQQPT PSPTRDRVGS GEWLADTEKL PGAAASPEDV VVASTHHAAA AARYVPPRAT
     SHTAEPNPGR DGGGGWYSWN GARRARHDPP APRRQQPAKT HPPAPPLPAA PPPPPPPPPA
     ASPAPAPRAP PPHAQVRSAD RVVPAILSRK RRAAVMQRAA LLARAAAAGX XLAALTVLAA
     DTRRGWARDS YSNYAQFRYS EAVNVVGFLY SVFQFVALAE LMRRNTHLIP HPKRGLFDFT
     MDQVLAYLLI SSSSSATARA SDLTENWGSD SFPNMANGSI AISFVAFVVF AICSLISAYN
     LFRRDM