ID   CSPLG_PHYPA             Reviewed;         182 AA.
AC   A9RLK6;
DT   05-SEP-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2012, sequence version 2.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=CASP-like protein 5A1;
DE            Short=PpCASPL5A1;
GN   ORFNames=PHYPADRAFT_55654;
OS   Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Bryophyta;
OC   Bryophytina; Bryopsida; Funariidae; Funariales; Funariaceae; Physcomitrium.
OX   NCBI_TaxID=3218;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Gransden 2004;
RX   PubMed=18079367; DOI=10.1126/science.1150646;
RA   Rensing S.A., Lang D., Zimmer A.D., Terry A., Salamov A., Shapiro H.,
RA   Nishiyama T., Perroud P.-F., Lindquist E.A., Kamisugi Y., Tanahashi T.,
RA   Sakakibara K., Fujita T., Oishi K., Shin-I T., Kuroki Y., Toyoda A.,
RA   Suzuki Y., Hashimoto S.-I., Yamaguchi K., Sugano S., Kohara Y.,
RA   Fujiyama A., Anterola A., Aoki S., Ashton N., Barbazuk W.B., Barker E.,
RA   Bennetzen J.L., Blankenship R., Cho S.H., Dutcher S.K., Estelle M.,
RA   Fawcett J.A., Gundlach H., Hanada K., Heyl A., Hicks K.A., Hughes J.,
RA   Lohr M., Mayer K., Melkozernov A., Murata T., Nelson D.R., Pils B.,
RA   Prigge M., Reiss B., Renner T., Rombauts S., Rushton P.J., Sanderfoot A.,
RA   Schween G., Shiu S.-H., Stueber K., Theodoulou F.L., Tu H., Van de Peer Y.,
RA   Verrier P.J., Waters E., Wood A., Yang L., Cove D., Cuming A.C., Hasebe M.,
RA   Lucas S., Mishler B.D., Reski R., Grigoriev I.V., Quatrano R.S.,
RA   Boore J.L.;
RT   "The Physcomitrella genome reveals evolutionary insights into the conquest
RT   of land by plants.";
RL   Science 319:64-69(2008).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Gransden 2004; TISSUE=Sporophyte;
RA   Kohara Y., Shin-i T., Nishiyama T., Suzuki Y., Sugano S., Hiwatashi Y.,
RA   Hasebe M.;
RT   "Expressed genes in Physcomitrella patens.";
RL   Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=24920445; DOI=10.1104/pp.114.239137;
RA   Roppolo D., Boeckmann B., Pfister A., Boutet E., Rubio M.C.,
RA   Denervaud-Tendon V., Vermeer J.E., Gheyselinck J., Xenarios I., Geldner N.;
RT   "Functional and evolutionary analysis of the CASPARIAN STRIP MEMBRANE
RT   DOMAIN PROTEIN family.";
RL   Plant Physiol. 165:1709-1722(2014).
CC   -!- SUBUNIT: Homodimer and heterodimers. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Casparian strip membrane proteins (CASP)
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDQ80312.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; DS544904; EDQ80312.1; ALT_INIT; Genomic_DNA.
DR   EMBL; DC944244; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; XP_001754858.1; XM_001754806.1.
DR   AlphaFoldDB; A9RLK6; -.
DR   STRING; 3218.PP1S15_474V6.1; -.
DR   EnsemblPlants; Pp3c16_4800V3.1; Pp3c16_4800V3.1; Pp3c16_4800.
DR   EnsemblPlants; Pp3c16_4800V3.2; Pp3c16_4800V3.2; Pp3c16_4800.
DR   Gramene; Pp3c16_4800V3.1; Pp3c16_4800V3.1; Pp3c16_4800.
DR   Gramene; Pp3c16_4800V3.2; Pp3c16_4800V3.2; Pp3c16_4800.
DR   eggNOG; ENOG502QTTS; Eukaryota.
DR   HOGENOM; CLU_103961_1_0_1; -.
DR   InParanoid; A9RLK6; -.
DR   OMA; WFCALPS; -.
DR   OrthoDB; 1282860at2759; -.
DR   Proteomes; UP000006727; Chromosome 16.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006702; CASP_dom.
DR   InterPro; IPR045009; CASPL-5.
DR   PANTHER; PTHR32021; PTHR32021; 1.
DR   Pfam; PF04535; DUF588; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..182
FT                   /note="CASP-like protein 5A1"
FT                   /id="PRO_0000418674"
FT   TOPO_DOM        1..47
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        69..72
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        94..117
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        139..158
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        180..182
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   182 AA;  19486 MW;  7B31B6FBE62EA6D0 CRC64;
     MEMASHPAVH PVALPPPYQA VGPPAPPAVR INDFPGSPGT LMGLALRFAQ LGFALTALCI
     MVSIVGFSSV TAFCFLVAAM VLQCIWSLCL GVLDCYALLT KRSLRNSLIL SFFVVGDWIT
     STMTFAGACA AAGITVLIDN DLNQCGPNHC NRFEAAAAMA FMSWVITTIS FFLSFWILVT
     CR