CSPLH_ARATH
ID CSPLH_ARATH Reviewed; 154 AA.
AC P0CB17; A0A1I9LP25; Q9SVL7;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=CASP-like protein 5C2;
DE Short=AtCASPL5C2;
GN OrderedLocusNames=At3g50810; ORFNames=F18B3.90;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=24920445; DOI=10.1104/pp.114.239137;
RA Roppolo D., Boeckmann B., Pfister A., Boutet E., Rubio M.C.,
RA Denervaud-Tendon V., Vermeer J.E., Gheyselinck J., Xenarios I., Geldner N.;
RT "Functional and evolutionary analysis of the CASPARIAN STRIP MEMBRANE
RT DOMAIN PROTEIN family.";
RL Plant Physiol. 165:1709-1722(2014).
CC -!- SUBUNIT: Homodimer and heterodimers. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Casparian strip membrane proteins (CASP)
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB42910.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 2 genes: At3g50808 and At3g50810.; Evidence={ECO:0000305};
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DR EMBL; AL049862; CAB42910.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE78713.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM64333.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM64334.1; -; Genomic_DNA.
DR PIR; T08402; T08402.
DR RefSeq; NP_001326370.1; NM_001339482.1.
DR RefSeq; NP_001326371.1; NM_001339483.1.
DR RefSeq; NP_190650.4; NM_114941.5.
DR AlphaFoldDB; P0CB17; -.
DR PaxDb; P0CB17; -.
DR EnsemblPlants; AT3G50810.1; AT3G50810.1; AT3G50810.
DR EnsemblPlants; AT3G50810.2; AT3G50810.2; AT3G50810.
DR EnsemblPlants; AT3G50810.3; AT3G50810.3; AT3G50810.
DR GeneID; 824245; -.
DR Gramene; AT3G50810.1; AT3G50810.1; AT3G50810.
DR Gramene; AT3G50810.2; AT3G50810.2; AT3G50810.
DR Gramene; AT3G50810.3; AT3G50810.3; AT3G50810.
DR KEGG; ath:AT3G50810; -.
DR Araport; AT3G50810; -.
DR TAIR; locus:2077962; AT3G50810.
DR eggNOG; ENOG502RZFM; Eukaryota.
DR HOGENOM; CLU_103961_1_0_1; -.
DR InParanoid; P0CB17; -.
DR OMA; AIPWSIT; -.
DR OrthoDB; 1505699at2759; -.
DR PhylomeDB; P0CB17; -.
DR PRO; PR:P0CB17; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; P0CB17; baseline and differential.
DR Genevisible; P0CB17; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR006702; CASP_dom.
DR InterPro; IPR045009; CASPL-5.
DR PANTHER; PTHR32021; PTHR32021; 1.
DR Pfam; PF04535; DUF588; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..154
FT /note="CASP-like protein 5C2"
FT /id="PRO_0000308670"
FT TOPO_DOM 1..17
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39..41
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..81
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..128
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..154
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 154 AA; 16824 MW; 2052B6A9208AE6B4 CRC64;
MEHVPGSFGT SASFALRFGQ TIFSAASLIF MCFDFDFYDF TTFCYLAMVM AIVTPWSILL
ALTDTYSVLV KLLPQELRVL SIVFAGDFVL SFLSLGGACA VASATELLAS ADGKICDGSL
CIQYQVSAAL AFLCWFLLLA SALFNFWSLP SLYY
