ID   CSPLH_MAIZE             Reviewed;         159 AA.
AC   B6U300;
DT   05-SEP-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2012, sequence version 2.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=CASP-like protein 5C1;
DE            Short=ZmCASPL5C1;
OS   Zea mays (Maize).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX   NCBI_TaxID=4577;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Flower, and Root;
RX   PubMed=18937034; DOI=10.1007/s11103-008-9415-4;
RA   Alexandrov N.N., Brover V.V., Freidin S., Troukhan M.E., Tatarinova T.V.,
RA   Zhang H., Swaller T.J., Lu Y.-P., Bouck J., Flavell R.B., Feldmann K.A.;
RT   "Insights into corn genes derived from large-scale cDNA sequencing.";
RL   Plant Mol. Biol. 69:179-194(2009).
RN   [2]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=24920445; DOI=10.1104/pp.114.239137;
RA   Roppolo D., Boeckmann B., Pfister A., Boutet E., Rubio M.C.,
RA   Denervaud-Tendon V., Vermeer J.E., Gheyselinck J., Xenarios I., Geldner N.;
RT   "Functional and evolutionary analysis of the CASPARIAN STRIP MEMBRANE
RT   DOMAIN PROTEIN family.";
RL   Plant Physiol. 165:1709-1722(2014).
CC   -!- SUBUNIT: Homodimer and heterodimers. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=B6U300-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=B6U300-2; Sequence=VSP_044078;
CC   -!- SIMILARITY: Belongs to the Casparian strip membrane proteins (CASP)
CC       family. {ECO:0000305}.
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DR   EMBL; EU971615; ACG43733.1; -; mRNA.
DR   EMBL; FL249491; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; NP_001144895.1; NM_001151423.1.
DR   RefSeq; XP_008671839.1; XM_008673617.1. [B6U300-1]
DR   AlphaFoldDB; B6U300; -.
DR   PaxDb; B6U300; -.
DR   EnsemblPlants; Zm00001eb058720_T003; Zm00001eb058720_P003; Zm00001eb058720. [B6U300-1]
DR   GeneID; 100278000; -.
DR   Gramene; Zm00001eb058720_T003; Zm00001eb058720_P003; Zm00001eb058720. [B6U300-1]
DR   eggNOG; ENOG502RYBF; Eukaryota.
DR   HOGENOM; CLU_103961_1_0_1; -.
DR   OMA; WNLTLAM; -.
DR   OrthoDB; 1505699at2759; -.
DR   Proteomes; UP000007305; Chromosome 1.
DR   ExpressionAtlas; B6U300; baseline and differential.
DR   Genevisible; B6U300; ZM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006702; CASP_dom.
DR   InterPro; IPR045009; CASPL-5.
DR   PANTHER; PTHR32021; PTHR32021; 1.
DR   Pfam; PF04535; DUF588; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..159
FT                   /note="CASP-like protein 5C1"
FT                   /id="PRO_0000418698"
FT   TOPO_DOM        1..6
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        7..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        30..48
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        70..94
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        118..134
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        156..159
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         62
FT                   /note="W -> LEA (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:18937034"
FT                   /id="VSP_044078"
SQ   SEQUENCE   159 AA;  16659 MW;  77510719082E208E CRC64;
     MDNGDRSGAG AGAVGSAGSL GLRVGQAVFS SASLLFMSVG VEFFSYTAFC FLVTIMGLVI
     PWSCTLAMID VYSVFVGCPL RVPGVMVIVV VGDCALSIVS FAAACSSAAV IDLLLQLHGS
     HSSPTFCGRY QLSAMMAFLS WLLMAASATF NLWFVASRW