ID   CSPLV_ARATH             Reviewed;         270 AA.
AC   Q9FNE8;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=CASP-like protein 4A1;
DE            Short=AtCASPL4A1;
GN   OrderedLocusNames=At5g40300; ORFNames=MPO12.1;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9405937; DOI=10.1093/dnares/4.4.291;
RA   Kotani H., Nakamura Y., Sato S., Kaneko T., Asamizu E., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. II. Sequence
RT   features of the regions of 1,044,062 bp covered by thirteen physically
RT   assigned P1 clones.";
RL   DNA Res. 4:291-300(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=24920445; DOI=10.1104/pp.114.239137;
RA   Roppolo D., Boeckmann B., Pfister A., Boutet E., Rubio M.C.,
RA   Denervaud-Tendon V., Vermeer J.E., Gheyselinck J., Xenarios I., Geldner N.;
RT   "Functional and evolutionary analysis of the CASPARIAN STRIP MEMBRANE
RT   DOMAIN PROTEIN family.";
RL   Plant Physiol. 165:1709-1722(2014).
CC   -!- SUBUNIT: Homodimer and heterodimers. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Casparian strip membrane proteins (CASP)
CC       family. {ECO:0000305}.
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DR   EMBL; AB006702; BAB11584.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED94531.1; -; Genomic_DNA.
DR   EMBL; BT010719; AAR20776.1; -; mRNA.
DR   EMBL; BT011792; AAS68116.1; -; mRNA.
DR   RefSeq; NP_198846.1; NM_123394.4.
DR   AlphaFoldDB; Q9FNE8; -.
DR   BioGRID; 19279; 2.
DR   IntAct; Q9FNE8; 2.
DR   STRING; 3702.AT5G40300.1; -.
DR   iPTMnet; Q9FNE8; -.
DR   PaxDb; Q9FNE8; -.
DR   PRIDE; Q9FNE8; -.
DR   ProteomicsDB; 222712; -.
DR   EnsemblPlants; AT5G40300.1; AT5G40300.1; AT5G40300.
DR   GeneID; 834028; -.
DR   Gramene; AT5G40300.1; AT5G40300.1; AT5G40300.
DR   KEGG; ath:AT5G40300; -.
DR   Araport; AT5G40300; -.
DR   TAIR; locus:2170603; AT5G40300.
DR   eggNOG; ENOG502QW75; Eukaryota.
DR   HOGENOM; CLU_048961_2_0_1; -.
DR   InParanoid; Q9FNE8; -.
DR   OMA; MENCQVR; -.
DR   OrthoDB; 1502083at2759; -.
DR   PhylomeDB; Q9FNE8; -.
DR   PRO; PR:Q9FNE8; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FNE8; baseline and differential.
DR   Genevisible; Q9FNE8; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IBA:GO_Central.
DR   InterPro; IPR006702; CASP_dom.
DR   Pfam; PF04535; DUF588; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..270
FT                   /note="CASP-like protein 4A1"
FT                   /id="PRO_0000308686"
FT   TOPO_DOM        1..121
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        143..161
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        183..198
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        222..246
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        268..270
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          1..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..80
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        82..97
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   270 AA;  30299 MW;  C4E680BED69F4CED CRC64;
     MEELEKTQKF QKKKKQQQEK QDQSSPINFE MSSRSSLHSL PQTTIESPPD SPTLSSIPDS
     HGSSPHTIIP TPSVAKTETP FRVTNGEEEK KVSESRRQLR PSFSSSSSTP RESKWASLIR
     KALLGFRVIA FVSCLVSFSV MVSDRDKGWA HDSFYNYKEF RFCLAANVIG FVYSGFMICD
     LVYLLSTSIR RSRHNLRHFL EFGLDQMLAY LLASASTSAS IRVDDWQSNW GADKFPDLAR
     ASVALSYVSF VAFAFCSLAS GYALCALRSI