ID   CSP_STROR               Reviewed;          41 AA.
AC   O33689;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Competence-stimulating peptide;
DE            Short=CSP;
DE   Flags: Precursor;
GN   Name=comC;
OS   Streptococcus oralis.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1303;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 35037 / CIP 102922 / DSM 20627 / KCTC 13048 / LMG 14532 / NCTC
RC   11427 / PB182;
RX   PubMed=9352904; DOI=10.1128/jb.179.21.6589-6594.1997;
RA   Haevarstein L.S., Hakenbeck R., Gaustad P.;
RT   "Natural competence in the genus Streptococcus: evidence that streptococci
RT   can change pherotype by interspecies recombinational exchanges.";
RL   J. Bacteriol. 179:6589-6594(1997).
CC   -!- FUNCTION: Acts as a pheromone, induces cells to develop competence for
CC       genetic transformation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the ComC family. {ECO:0000305}.
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DR   EMBL; AJ000873; CAA04363.1; -; Genomic_DNA.
DR   RefSeq; WP_002874960.1; NZ_RMVJ01000025.1.
DR   AlphaFoldDB; O33689; -.
DR   SMR; O33689; -.
DR   GeneID; 49600699; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005186; F:pheromone activity; IEA:UniProtKB-KW.
DR   GO; GO:0030420; P:establishment of competence for transformation; IEA:UniProtKB-KW.
DR   InterPro; IPR010133; Bacteriocin_signal_seq.
DR   InterPro; IPR004288; Competence_ComC.
DR   Pfam; PF03047; ComC; 1.
DR   TIGRFAMs; TIGR01847; bacteriocin_sig; 1.
PE   3: Inferred from homology;
KW   Competence; Pheromone; Secreted.
FT   PROPEP          1..24
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000005877"
FT   PEPTIDE         25..41
FT                   /note="Competence-stimulating peptide"
FT                   /id="PRO_0000005878"
SQ   SEQUENCE   41 AA;  4988 MW;  1276E5B6F72A1463 CRC64;
     MKNTEKLEQF KEVTEAELQE IRGGDKRLPY FFKHLFSNRT K