ID   CSRA_SERMA              Reviewed;          69 AA.
AC   O85735;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Translational regulator CsrA {ECO:0000255|HAMAP-Rule:MF_00167};
DE   AltName: Full=Carbon storage regulator {ECO:0000255|HAMAP-Rule:MF_00167};
DE   AltName: Full=Repressor of secondary metabolites {ECO:0000303|PubMed:11287746};
GN   Name=csrA {ECO:0000255|HAMAP-Rule:MF_00167};
GN   Synonyms=rsmA {ECO:0000303|PubMed:11287746};
OS   Serratia marcescens.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Serratia.
OX   NCBI_TaxID=615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION, AND DISRUPTION
RP   PHENOTYPE.
RC   STRAIN=CH1, and SS-1;
RX   PubMed=11287746; DOI=10.1159/000054028;
RA   Ang S., Horng Y.-T., Shu J.-C., Soo P.-C., Liu J.-H., Yi W.-C., Lai H.-C.,
RA   Luh K.-T., Ho S.-W., Swift S.;
RT   "The role of RsmA in the regulation of swarming motility in Serratia
RT   marcescens.";
RL   J. Biomed. Sci. 8:160-169(2001).
CC   -!- FUNCTION: A key translational regulator that binds mRNA to regulate
CC       translation initiation and/or mRNA stability. Mediates global changes
CC       in gene expression, shifting from rapid growth to stress survival by
CC       linking envelope stress, the stringent response and the catabolite
CC       repression systems. Usually binds in the 5'-UTR; binding at or near the
CC       Shine-Dalgarno sequence prevents ribosome-binding, repressing
CC       translation, binding elsewhere in the 5'-UTR can activate translation
CC       and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
CC       {ECO:0000255|HAMAP-Rule:MF_00167}.
CC   -!- FUNCTION: Involved in the process of swarming and quorum-sensing signal
CC       production; overexpression strongly inhibits swarming motility, pigment
CC       and N-acylhomoserine lactone (quorum-sensing signal) production but not
CC       swimming motility or swarmer cell differentiation (PubMed:11287746).
CC       {ECO:0000269|PubMed:11287746}.
CC   -!- SUBUNIT: Homodimer; the beta-strands of each monomer intercalate to
CC       form a hydrophobic core, while the alpha-helices form wings that extend
CC       away from the core. {ECO:0000255|HAMAP-Rule:MF_00167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00167}.
CC   -!- INDUCTION: Transcription peaks early in exponential phase, is greater
CC       at 37 than 30 degrees Celsius (PubMed:11287746).
CC       {ECO:0000269|PubMed:11287746}.
CC   -!- DISRUPTION PHENOTYPE: Swarming motility inititates later than in wild-
CC       type; once inititated the swarming velocity is normal
CC       (PubMed:11287746). {ECO:0000269|PubMed:11287746}.
CC   -!- SIMILARITY: Belongs to the CsrA/RsmA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00167}.
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DR   EMBL; AF074437; AAC25783.1; -; Genomic_DNA.
DR   EMBL; AJ243121; CAB45388.1; -; Genomic_DNA.
DR   AlphaFoldDB; O85735; -.
DR   SMR; O85735; -.
DR   STRING; 273526.SMDB11_0161; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0048027; F:mRNA 5'-UTR binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:InterPro.
DR   GO; GO:0045947; P:negative regulation of translational initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0045948; P:positive regulation of translational initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006109; P:regulation of carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.40.4380; -; 1.
DR   HAMAP; MF_00167; CsrA; 1.
DR   InterPro; IPR003751; CsrA.
DR   InterPro; IPR036107; CsrA_sf.
DR   PANTHER; PTHR34984; PTHR34984; 1.
DR   Pfam; PF02599; CsrA; 1.
DR   SUPFAM; SSF117130; SSF117130; 1.
DR   TIGRFAMs; TIGR00202; csrA; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cytoplasm; Repressor; RNA-binding; Translation regulation.
FT   CHAIN           1..69
FT                   /note="Translational regulator CsrA"
FT                   /id="PRO_0000177089"
SQ   SEQUENCE   69 AA;  7696 MW;  2256A78C31BD3F50 CRC64;
     MLILTRRVGE TLMIGDEVTV TVLGVKGNQV RIGVNAPKEV SVHREEIYQR IQAEKSADDL
     LIPKQRLVA