CSRN1_HUMAN
ID CSRN1_HUMAN Reviewed; 589 AA.
AC Q96S65; Q69YY5;
DT 25-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Cysteine/serine-rich nuclear protein 1;
DE Short=CSRNP-1;
DE AltName: Full=Axin-1 up-regulated gene 1 protein;
DE AltName: Full=Protein URAX1;
DE AltName: Full=TGF-beta-induced apoptosis protein 3;
DE Short=TAIP-3;
GN Name=CSRNP1; Synonyms=AXUD1, TAIP3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND VARIANT
RP ILE-453.
RX PubMed=11526492; DOI=10.1038/sj.onc.1204603;
RA Ishiguro H., Tsunoda T., Tanaka T., Fujii Y., Nakamura Y., Furukawa Y.;
RT "Identification of AXUD1, a novel human gene induced by AXIN1 and its
RT reduced expression in human carcinomas of the lung, liver, colon and
RT kidney.";
RL Oncogene 20:5062-5066(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ILE-453.
RA Akiyama N., Kondoh S.;
RT "TGF-beta induced apoptosis protein 3 (TAIP-3).";
RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ILE-453.
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 530-589.
RC TISSUE=Kidney;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- FUNCTION: Binds to the consensus sequence 5'-AGAGTG-3' and has
CC transcriptional activator activity (By similarity). May have a tumor-
CC suppressor function. May play a role in apoptosis. {ECO:0000250,
CC ECO:0000269|PubMed:11526492}.
CC -!- INTERACTION:
CC Q96S65; P29972: AQP1; NbExp=3; IntAct=EBI-4311573, EBI-745213;
CC Q96S65; Q96EZ8: MCRS1; NbExp=3; IntAct=EBI-4311573, EBI-348259;
CC Q96S65; P62136: PPP1CA; NbExp=8; IntAct=EBI-4311573, EBI-357253;
CC Q96S65; P62140: PPP1CB; NbExp=3; IntAct=EBI-4311573, EBI-352350;
CC Q96S65; P36873: PPP1CC; NbExp=3; IntAct=EBI-4311573, EBI-356283;
CC Q96S65; Q99633: PRPF18; NbExp=3; IntAct=EBI-4311573, EBI-2798416;
CC Q96S65; Q8N8B7: TCEANC; NbExp=3; IntAct=EBI-4311573, EBI-954696;
CC Q96S65; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-4311573, EBI-11955057;
CC Q96S65; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-4311573, EBI-740727;
CC Q96S65; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-4311573, EBI-6427977;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. Most abundantly expressed in lung,
CC placenta, skeletal muscle, pancreas and leukocyte. Frequently down-
CC regulated in lung, kidney, liver and colon cancers compared with their
CC corresponding normal tissues. {ECO:0000269|PubMed:11526492}.
CC -!- SIMILARITY: Belongs to the AXUD1 family. {ECO:0000305}.
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DR EMBL; AB053121; BAB61065.1; -; mRNA.
DR EMBL; AB063301; BAB79450.1; -; mRNA.
DR EMBL; AC092053; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC038949; AAH38949.1; -; mRNA.
DR EMBL; AL117565; CAH10719.1; -; mRNA.
DR CCDS; CCDS2682.1; -.
DR RefSeq; NP_001307489.1; NM_001320560.1.
DR RefSeq; NP_149016.2; NM_033027.3.
DR RefSeq; XP_016862537.1; XM_017007048.1.
DR AlphaFoldDB; Q96S65; -.
DR BioGRID; 122227; 75.
DR IntAct; Q96S65; 10.
DR STRING; 9606.ENSP00000273153; -.
DR iPTMnet; Q96S65; -.
DR PhosphoSitePlus; Q96S65; -.
DR BioMuta; CSRNP1; -.
DR DMDM; 308153432; -.
DR jPOST; Q96S65; -.
DR MassIVE; Q96S65; -.
DR PaxDb; Q96S65; -.
DR PeptideAtlas; Q96S65; -.
DR PRIDE; Q96S65; -.
DR ProteomicsDB; 78076; -.
DR Antibodypedia; 12159; 149 antibodies from 29 providers.
DR DNASU; 64651; -.
DR Ensembl; ENST00000273153.10; ENSP00000273153.5; ENSG00000144655.15.
DR Ensembl; ENST00000514182.1; ENSP00000422532.1; ENSG00000144655.15.
DR GeneID; 64651; -.
DR KEGG; hsa:64651; -.
DR MANE-Select; ENST00000273153.10; ENSP00000273153.5; NM_033027.4; NP_149016.2.
DR UCSC; uc003cjg.4; human.
DR CTD; 64651; -.
DR DisGeNET; 64651; -.
DR GeneCards; CSRNP1; -.
DR HGNC; HGNC:14300; CSRNP1.
DR HPA; ENSG00000144655; Tissue enhanced (bone).
DR MIM; 606458; gene.
DR neXtProt; NX_Q96S65; -.
DR OpenTargets; ENSG00000144655; -.
DR PharmGKB; PA25200; -.
DR VEuPathDB; HostDB:ENSG00000144655; -.
DR eggNOG; KOG3813; Eukaryota.
DR GeneTree; ENSGT00950000183072; -.
DR HOGENOM; CLU_034103_2_2_1; -.
DR InParanoid; Q96S65; -.
DR OMA; CHCDRVC; -.
DR OrthoDB; 577123at2759; -.
DR PhylomeDB; Q96S65; -.
DR TreeFam; TF323969; -.
DR PathwayCommons; Q96S65; -.
DR SignaLink; Q96S65; -.
DR BioGRID-ORCS; 64651; 21 hits in 1087 CRISPR screens.
DR ChiTaRS; CSRNP1; human.
DR GenomeRNAi; 64651; -.
DR Pharos; Q96S65; Tbio.
DR PRO; PR:Q96S65; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q96S65; protein.
DR Bgee; ENSG00000144655; Expressed in mucosa of stomach and 164 other tissues.
DR ExpressionAtlas; Q96S65; baseline and differential.
DR Genevisible; Q96S65; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; NAS:UniProtKB.
DR GO; GO:0060325; P:face morphogenesis; IEA:Ensembl.
DR GO; GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060021; P:roof of mouth development; IEA:Ensembl.
DR GO; GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
DR InterPro; IPR031972; CSRNP_N.
DR InterPro; IPR023260; Cys/Ser-rich_nuc_prot.
DR PANTHER; PTHR13580; PTHR13580; 1.
DR Pfam; PF16019; CSRNP_N; 1.
DR PRINTS; PR02031; CYSSERRICHNP.
PE 1: Evidence at protein level;
KW Activator; Apoptosis; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..589
FT /note="Cysteine/serine-rich nuclear protein 1"
FT /id="PRO_0000114786"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 453
FT /note="V -> I (in dbSNP:rs1274958)"
FT /evidence="ECO:0000269|PubMed:11526492,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
FT /id="VAR_055100"
SQ SEQUENCE 589 AA; 63508 MW; BAF4951B6F96ADD8 CRC64;
MTGLLKRKFD QLDEDNSSVS SSSSSSGCQS RSCSPSSSVS RAWDSEEEGP WDQMPLPDRD
FCGPRSFTPL SILKRARRER PGRVAFDGIT VFYFPRCQGF TSVPSRGGCT LGMALRHSAC
RRFSLAEFAQ EQARARHEKL RQRLKEEKLE MLQWKLSAAG VPQAEAGLPP VVDAIDDASV
EEDLAVAVAG GRLEEVSFLQ PYPARRRRAL LRASGVRRID REEKRELQAL RQSREDCGCH
CDRICDPETC SCSLAGIKCQ MDHTAFPCGC CREGCENPMG RVEFNQARVQ THFIHTLTRL
QLEQEAESFR ELEAPAQGSP PSPGEEALVP TFPLAKPPMN NELGDNSCSS DMTDSSTASS
SASGTSEAPD CPTHPGLPGP GFQPGVDDDS LARILSFSDS DFGGEEEEEE EGSVGNLDNL
SCFHPADIFG TSDPGGLASW THSYSGCSFT SGVLDENANL DASCFLNGGL EGSREGSLPG
TSVPPSMDAG RSSSVDLSLS SCDSFELLQA LPDYSLGPHY TSQKVSDSLD NIEAPHFPLP
GLSPPGDASS CFLESLMGFS EPAAEALDPF IDSQFEDTVP ASLMEPVPV
