CSRN2_MOUSE
ID CSRN2_MOUSE Reviewed; 534 AA.
AC Q8BGQ2; Q3UIH1;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Cysteine/serine-rich nuclear protein 2;
DE Short=CSRNP-2;
DE AltName: Full=Protein FAM130A1;
DE AltName: Full=TGF-beta-induced apoptosis protein 12;
DE Short=TAIP-12;
GN Name=Csrnp2; Synonyms=Fam130a1, Taip12;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Brain;
RA Akiyama N., Saitoh S., Yamada H., Kondoh S.K.;
RT "TGF-beta induced apoptosis protein 12 (TAIP-12).";
RL Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=17726538; DOI=10.1371/journal.pone.0000808;
RA Gingras S., Pelletier S., Boyd K., Ihle J.N.;
RT "Characterization of a family of novel cysteine- serine-rich nuclear
RT proteins (CSRNP).";
RL PLoS ONE 2:E808-E808(2007).
CC -!- FUNCTION: Binds to the consensus sequence 5'-AGAGTG-3' and has
CC transcriptional activator activity. May play a role in apoptosis.
CC {ECO:0000269|PubMed:17726538}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17726538}.
CC -!- TISSUE SPECIFICITY: Highest expression detected in thymus, brain and
CC ovary. Low levels detected in naive T-cells.
CC {ECO:0000269|PubMed:17726538}.
CC -!- DISRUPTION PHENOTYPE: Mice display no obvious defects in development,
CC hematopoiesis or T-cell function. Deletion of Axud1, Csrnp2 and Csrnp3
CC together causes partial neonatal lethality, suggesting that they have
CC redundant functions. {ECO:0000269|PubMed:17726538}.
CC -!- SIMILARITY: Belongs to the AXUD1 family. {ECO:0000305}.
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DR EMBL; AB091689; BAC16316.1; -; mRNA.
DR EMBL; AK050864; BAC34438.1; -; mRNA.
DR EMBL; AK146924; BAE27535.1; -; mRNA.
DR EMBL; BC035295; AAH35295.1; -; mRNA.
DR CCDS; CCDS27839.1; -.
DR RefSeq; NP_700456.1; NM_153407.2.
DR AlphaFoldDB; Q8BGQ2; -.
DR STRING; 10090.ENSMUSP00000052144; -.
DR iPTMnet; Q8BGQ2; -.
DR PhosphoSitePlus; Q8BGQ2; -.
DR MaxQB; Q8BGQ2; -.
DR PaxDb; Q8BGQ2; -.
DR PRIDE; Q8BGQ2; -.
DR ProteomicsDB; 283961; -.
DR Antibodypedia; 14333; 278 antibodies from 29 providers.
DR DNASU; 207785; -.
DR Ensembl; ENSMUST00000061457; ENSMUSP00000052144; ENSMUSG00000044636.
DR GeneID; 207785; -.
DR KEGG; mmu:207785; -.
DR UCSC; uc007xrk.1; mouse.
DR CTD; 81566; -.
DR MGI; MGI:2386852; Csrnp2.
DR VEuPathDB; HostDB:ENSMUSG00000044636; -.
DR eggNOG; KOG3813; Eukaryota.
DR GeneTree; ENSGT00950000183072; -.
DR HOGENOM; CLU_034103_0_1_1; -.
DR InParanoid; Q8BGQ2; -.
DR OMA; CGNVAGR; -.
DR OrthoDB; 577123at2759; -.
DR PhylomeDB; Q8BGQ2; -.
DR TreeFam; TF323969; -.
DR BioGRID-ORCS; 207785; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Csrnp2; mouse.
DR PRO; PR:Q8BGQ2; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q8BGQ2; protein.
DR Bgee; ENSMUSG00000044636; Expressed in animal zygote and 219 other tissues.
DR Genevisible; Q8BGQ2; MM.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0019902; F:phosphatase binding; ISS:UniProtKB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR031972; CSRNP_N.
DR InterPro; IPR023260; Cys/Ser-rich_nuc_prot.
DR PANTHER; PTHR13580; PTHR13580; 1.
DR Pfam; PF16019; CSRNP_N; 1.
DR PRINTS; PR02031; CYSSERRICHNP.
PE 2: Evidence at transcript level;
KW Acetylation; Activator; Apoptosis; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..534
FT /note="Cysteine/serine-rich nuclear protein 2"
FT /id="PRO_0000114791"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 479..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..521
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9H175"
SQ SEQUENCE 534 AA; 58504 MW; 7F09135767AE1D46 CRC64;
MDAFSGSGLK RKFDDVDVGS SVSNSDDEMS SSDSADSCDS LNPPTTASFT PTSILKRQKQ
LRRKNVRFDQ VTVYYFARRQ GFTSVPSQGG SSLGMAQRHN SVRSYTLCEF AQEQEVNHRE
ILREHLKEEK LHAKKMKLTK NGTVESVEAD GLTLDDVSDE DIDVENVEVD DYFFLQPLPT
KRRRALLRAS GVHRIDAEEK QELRAIRLSR EECGCDCRLY CDPEACACSQ AGIKCQVDRM
SFPCGCSRDG CGNMAGRIEF NPIRVRTHYL HTIMKLELES KRQVSRPAAE EEPLPGAQSS
QTQDFQEFIA ENETAVMHLQ SAEELERLKA EEDSSGSSAS LDSSMESLGV CILEEPLAVP
QELCPGLAAP ILIQAQLPPG SSVLCFTENS EHPAASPMSS PSYLNSGPLV YYQVEQRPVV
GVKAESGSEE GPASFPKEKD LSVFSLPVTS LVACGPSASA ALCKPEVGKT SSLNKLLPED
CGLKEPESED LHPSWSPSSL PFRTDNEEGC GVQNSQQSED RTSEDSALEL PLAV
