CSRN3_HUMAN
ID CSRN3_HUMAN Reviewed; 585 AA.
AC Q8WYN3; B3KPR4; Q53SG0; Q6ZTX3; Q9HAF9;
DT 25-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Cysteine/serine-rich nuclear protein 3;
DE Short=CSRNP-3;
DE AltName: Full=Protein FAM130A2;
DE AltName: Full=TGF-beta-induced apoptosis protein 2;
DE Short=TAIP-2;
GN Name=CSRNP3; Synonyms=FAM130A2, TAIP2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Akiyama N., Kondoh S.;
RT "TGF-beta induced apoptosis protein 2 (TAIP-2).";
RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, Embryo, and Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP VARIANT [LARGE SCALE ANALYSIS] LEU-474.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Binds to the consensus sequence 5'-AGAGTG-3' and has
CC transcriptional activator activity. Plays a role in apoptosis (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8WYN3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WYN3-2; Sequence=VSP_034258, VSP_034259;
CC -!- SIMILARITY: Belongs to the AXUD1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB13890.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC86454.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAC86454.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305};
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DR EMBL; AB063300; BAB79449.1; -; mRNA.
DR EMBL; AK021765; BAB13890.1; ALT_INIT; mRNA.
DR EMBL; AK056655; BAG51776.1; -; mRNA.
DR EMBL; AK126129; BAC86454.1; ALT_FRAME; mRNA.
DR EMBL; AC019140; AAY24139.1; -; Genomic_DNA.
DR EMBL; CH471058; EAX11326.1; -; Genomic_DNA.
DR CCDS; CCDS2225.1; -. [Q8WYN3-1]
DR RefSeq; NP_001165644.1; NM_001172173.1. [Q8WYN3-1]
DR RefSeq; NP_079245.2; NM_024969.3. [Q8WYN3-1]
DR AlphaFoldDB; Q8WYN3; -.
DR BioGRID; 123083; 2.
DR ELM; Q8WYN3; -.
DR IntAct; Q8WYN3; 2.
DR STRING; 9606.ENSP00000318258; -.
DR GlyGen; Q8WYN3; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q8WYN3; -.
DR PhosphoSitePlus; Q8WYN3; -.
DR BioMuta; CSRNP3; -.
DR DMDM; 24418715; -.
DR MassIVE; Q8WYN3; -.
DR PaxDb; Q8WYN3; -.
DR PeptideAtlas; Q8WYN3; -.
DR PRIDE; Q8WYN3; -.
DR Antibodypedia; 19202; 127 antibodies from 23 providers.
DR DNASU; 80034; -.
DR Ensembl; ENST00000314499.11; ENSP00000318258.7; ENSG00000178662.16. [Q8WYN3-1]
DR Ensembl; ENST00000342316.8; ENSP00000344042.4; ENSG00000178662.16. [Q8WYN3-1]
DR Ensembl; ENST00000651982.1; ENSP00000498841.1; ENSG00000178662.16. [Q8WYN3-1]
DR GeneID; 80034; -.
DR KEGG; hsa:80034; -.
DR MANE-Select; ENST00000651982.1; ENSP00000498841.1; NM_001172173.2; NP_001165644.1.
DR UCSC; uc002udf.3; human. [Q8WYN3-1]
DR CTD; 80034; -.
DR DisGeNET; 80034; -.
DR GeneCards; CSRNP3; -.
DR HGNC; HGNC:30729; CSRNP3.
DR HPA; ENSG00000178662; Tissue enhanced (brain).
DR neXtProt; NX_Q8WYN3; -.
DR OpenTargets; ENSG00000178662; -.
DR PharmGKB; PA164718184; -.
DR VEuPathDB; HostDB:ENSG00000178662; -.
DR eggNOG; KOG3813; Eukaryota.
DR GeneTree; ENSGT00950000183072; -.
DR HOGENOM; CLU_034103_1_0_1; -.
DR InParanoid; Q8WYN3; -.
DR OrthoDB; 577123at2759; -.
DR PhylomeDB; Q8WYN3; -.
DR TreeFam; TF323969; -.
DR PathwayCommons; Q8WYN3; -.
DR SignaLink; Q8WYN3; -.
DR BioGRID-ORCS; 80034; 17 hits in 1068 CRISPR screens.
DR ChiTaRS; CSRNP3; human.
DR GenomeRNAi; 80034; -.
DR Pharos; Q8WYN3; Tdark.
DR PRO; PR:Q8WYN3; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q8WYN3; protein.
DR Bgee; ENSG00000178662; Expressed in Brodmann (1909) area 23 and 157 other tissues.
DR ExpressionAtlas; Q8WYN3; baseline and differential.
DR Genevisible; Q8WYN3; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR031972; CSRNP_N.
DR InterPro; IPR023260; Cys/Ser-rich_nuc_prot.
DR PANTHER; PTHR13580; PTHR13580; 1.
DR Pfam; PF16019; CSRNP_N; 1.
DR PRINTS; PR02031; CYSSERRICHNP.
PE 2: Evidence at transcript level;
KW Activator; Alternative splicing; Apoptosis; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..585
FT /note="Cysteine/serine-rich nuclear protein 3"
FT /id="PRO_0000114788"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 335..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..351
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..391
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1
FT /note="M -> MRSQGTCDSTAA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034258"
FT VAR_SEQ 439..508
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034259"
FT VARIANT 474
FT /note="P -> L (in a colorectal cancer sample; somatic
FT mutation; dbSNP:rs766623860)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035993"
SQ SEQUENCE 585 AA; 64900 MW; 3CA2E6A0CCFD01CB CRC64;
MSGILKRKFE EVDGSSPCSS VRESDDEVSS SESADSGDSV NPSTSSHFTP SSILKREKRL
RTKNVHFSCV TVYYFTRRQG FTSVPSQGGS TLGMSSRHNS VRQYTLGEFA REQERLHREM
LREHLREEKL NSLKLKMTKN GTVESEEAST LTLDDISDDD IDLDNTEVDE YFFLQPLPTK
KRRALLRASG VKKIDVEEKH ELRAIRLSRE DCGCDCRVFC DPDTCTCSLA GIKCQVDRMS
FPCGCTKEGC SNTAGRIEFN PIRVRTHFLH TIMKLELEKN REQQIPTLNG CHSEISAHSS
SMGPVAHSVE YSIADSFEIE TEPQAAVLHL QSAEELDCQG EEEEEEEDGS SFCSGVTDSS
TQSLAPSESD EEEEEEEEEE EEEDDDDDKG DGFVEGLGTH AEVVPLPSVL CYSDGTAVHE
SHAKNASFYA NSSTLYYQID SHIPGTPNQI SENYSERDTV KNGTLSLVPY TMTPEQFVDY
ARQAEEAYGA SHYPAANPSV IVCCSSSEND SGVPCNSLYP EHRSNHPQVE FHSYLKGPSQ
EGFVSALNGD SHISEHPAEN SLSLAEKSIL HEECIKSPVV ETVPV
