CSRN3_MOUSE
ID CSRN3_MOUSE Reviewed; 597 AA.
AC P59055; A3F6Q4; Q8BUT9; Q8BYL1;
DT 25-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Cysteine/serine-rich nuclear protein 3;
DE Short=CSRNP-3;
DE AltName: Full=Protein FAM130A2;
DE AltName: Full=TGF-beta-induced apoptosis protein 2;
DE Short=TAIP-2;
GN Name=Csrnp3; Synonyms=Fam130a2, Mbu1, Taip2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=17433858; DOI=10.1016/j.gene.2007.03.005;
RA Yang H.L., Cho E.Y., Han K.H., Kim H., Kim S.J.;
RT "Characterization of a novel mouse brain gene (mbu-1) identified by digital
RT differential display.";
RL Gene 395:144-150(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION, AND
RP TISSUE SPECIFICITY.
RC STRAIN=BALB/cJ; TISSUE=Fetal brain;
RX PubMed=18291095; DOI=10.1016/j.bbrc.2008.02.041;
RA Yamada K., Akiyama N., Yamada S., Tanaka H., Saito S., Hiraoka M.,
RA Kizaka-Kondoh S.;
RT "Taip2 is a novel cell death-related gene expressed in the brain during
RT development.";
RL Biochem. Biophys. Res. Commun. 369:426-431(2008).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Hypothalamus, and Visual cortex;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=17726538; DOI=10.1371/journal.pone.0000808;
RA Gingras S., Pelletier S., Boyd K., Ihle J.N.;
RT "Characterization of a family of novel cysteine- serine-rich nuclear
RT proteins (CSRNP).";
RL PLoS ONE 2:E808-E808(2007).
CC -!- FUNCTION: Binds to the consensus sequence 5'-AGAGTG-3' and has
CC transcriptional activator activity. Plays a role in apoptosis.
CC {ECO:0000269|PubMed:17726538, ECO:0000269|PubMed:18291095}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17726538,
CC ECO:0000269|PubMed:18291095}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P59055-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P59055-2; Sequence=VSP_034260;
CC -!- TISSUE SPECIFICITY: Detected only in the brain of 15 dpc, 18 dpc,
CC newborn and P6 mice (at protein level). {ECO:0000269|PubMed:17726538,
CC ECO:0000269|PubMed:18291095}.
CC -!- DEVELOPMENTAL STAGE: Expressed during embryonic development and also
CC detected a week after birth. Expression decreases by 14 days after
CC birth and is not detected in the adult (at protein level).
CC -!- DISRUPTION PHENOTYPE: Mice display no obvious defects in development,
CC hematopoiesis or T-cell function. Deletion of Axud1, Csnrp2 and Csnrp3
CC together causes partial neonatal lethality, suggesting that they have
CC redundant functions. {ECO:0000269|PubMed:17726538}.
CC -!- SIMILARITY: Belongs to the AXUD1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABN14256.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC30257.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; EF210820; ABN14256.1; ALT_INIT; mRNA.
DR EMBL; AB091688; BAC16315.1; -; mRNA.
DR EMBL; AK039150; BAC30257.1; ALT_INIT; mRNA.
DR EMBL; AK082649; BAC38559.1; -; mRNA.
DR EMBL; AK158873; BAE34706.1; -; mRNA.
DR EMBL; AL929230; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL935061; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS16074.2; -. [P59055-1]
DR CCDS; CCDS71060.1; -. [P59055-2]
DR RefSeq; NP_001277594.1; NM_001290665.1. [P59055-2]
DR RefSeq; NP_700458.3; NM_153409.5. [P59055-1]
DR RefSeq; NP_848749.2; NM_178634.2. [P59055-1]
DR RefSeq; XP_006500465.1; XM_006500402.2. [P59055-2]
DR RefSeq; XP_006500466.1; XM_006500403.3.
DR AlphaFoldDB; P59055; -.
DR STRING; 10090.ENSMUSP00000117533; -.
DR PhosphoSitePlus; P59055; -.
DR MaxQB; P59055; -.
DR PaxDb; P59055; -.
DR PRIDE; P59055; -.
DR ProteomicsDB; 283962; -. [P59055-1]
DR ProteomicsDB; 283963; -. [P59055-2]
DR Antibodypedia; 19202; 127 antibodies from 23 providers.
DR Ensembl; ENSMUST00000053910; ENSMUSP00000055719; ENSMUSG00000044647. [P59055-1]
DR Ensembl; ENSMUST00000112394; ENSMUSP00000108013; ENSMUSG00000044647. [P59055-2]
DR Ensembl; ENSMUST00000122912; ENSMUSP00000117533; ENSMUSG00000044647. [P59055-1]
DR Ensembl; ENSMUST00000145598; ENSMUSP00000135605; ENSMUSG00000044647. [P59055-2]
DR Ensembl; ENSMUST00000176109; ENSMUSP00000135019; ENSMUSG00000044647. [P59055-2]
DR GeneID; 77771; -.
DR KEGG; mmu:77771; -.
DR UCSC; uc008jwq.2; mouse. [P59055-1]
DR CTD; 80034; -.
DR MGI; MGI:1925021; Csrnp3.
DR VEuPathDB; HostDB:ENSMUSG00000044647; -.
DR eggNOG; KOG3813; Eukaryota.
DR GeneTree; ENSGT00950000183072; -.
DR HOGENOM; CLU_034103_1_0_1; -.
DR InParanoid; P59055; -.
DR OMA; MEGLGTH; -.
DR OrthoDB; 577123at2759; -.
DR PhylomeDB; P59055; -.
DR TreeFam; TF323969; -.
DR BioGRID-ORCS; 77771; 0 hits in 58 CRISPR screens.
DR ChiTaRS; Csrnp3; mouse.
DR PRO; PR:P59055; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; P59055; protein.
DR Bgee; ENSMUSG00000044647; Expressed in subparaventricular zone and 142 other tissues.
DR ExpressionAtlas; P59055; baseline and differential.
DR Genevisible; P59055; MM.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR031972; CSRNP_N.
DR InterPro; IPR023260; Cys/Ser-rich_nuc_prot.
DR PANTHER; PTHR13580; PTHR13580; 1.
DR Pfam; PF16019; CSRNP_N; 1.
DR PRINTS; PR02031; CYSSERRICHNP.
PE 1: Evidence at protein level;
KW Activator; Alternative splicing; Apoptosis; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..597
FT /note="Cysteine/serine-rich nuclear protein 3"
FT /id="PRO_0000114789"
FT REGION 22..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 348..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..403
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..12
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072,
FT ECO:0000303|PubMed:18291095"
FT /id="VSP_034260"
FT CONFLICT 246
FT /note="C -> R (in Ref. 2; BAC16315)"
FT /evidence="ECO:0000305"
FT CONFLICT 304
FT /note="H -> R (in Ref. 2; BAC16315)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 597 AA; 66121 MW; 20AEA5E37793E522 CRC64;
MRSQGTCDNA AAMSGILKRK FEDVDASSPC SSARESDDEV SSSESADSGD SVNPSTSNHF
TPSSILKREK RLRTKNVHFS CVTVYYFTRR QGFTSVPSQG GSTLGMSSRH NSVRQYTLGE
FAREQERLHR EMLREHLREE KLNSLKLKMT KNGTVESEEA STLTVDDISD DDIDLDNTEV
DEYFFLQPLP TKKRRALLRA SGVKKIDVDE KHELRAIRLS REDCGCDCRV FCDPETCTCS
LAGIKCQVDR MSFPCGCTKE GCSNTAGRIE FNPIRVRTHF LHTIMKLELE KNREQQTPTL
NGCHGEISAH GPSMGPVAHS VEYSIADNFE IETEPQAAVL HLQEELDCQG DEEEEEEDGS
SFCSGATDSS TQSLAPSESD EEEEEEEEEE EEEEEDDDDD KGDGFVEGLG AHTEVVPLPS
VLCYSDGTAV HESHTKNASF YASSSTLYYQ IDSHIPGTPS QLSDNYSERD TVKNGALSLV
PYAMTPERFV DYARQAEEAY GASHYPAANP SVIVCCPTSE NDSGVPCNPL YPEHRSNLPQ
VEFHSYLKGP AQEGFVSTLN GDSHISEHPA ENPLSLAEKS RLHEECIQSP VVETVPV
