ID   CSRP1_COTJA             Reviewed;         192 AA.
AC   P67967; P32965;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Cysteine and glycine-rich protein 1;
DE   AltName: Full=Cysteine-rich protein 1;
DE            Short=CRP;
DE            Short=CRP1;
GN   Name=CSRP1; Synonyms=CSRP;
OS   Coturnix japonica (Japanese quail) (Coturnix coturnix japonica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Perdicinae; Coturnix.
OX   NCBI_TaxID=93934;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryonic fibroblast;
RX   PubMed=7499425; DOI=10.1074/jbc.270.48.28946;
RA   Weiskirchen R., Pino J.D., Macalma T., Bister K., Beckerle M.C.;
RT   "The cysteine-rich protein family of highly related LIM domain proteins.";
RL   J. Biol. Chem. 270:28946-28954(1995).
CC   -!- FUNCTION: Heat stable protein, that interacts with zyxin/ZYX. May be a
CC       component of a signal transduction pathway that mediates adhesion-
CC       stimulated changes in gene expression. {ECO:0000250|UniProtKB:P67966}.
CC   -!- SUBUNIT: Interacts with ZYX. {ECO:0000250|UniProtKB:P67966}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P21291}. Cytoplasm
CC       {ECO:0000250|UniProtKB:P67966}. Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:P67966}. Note=Associates with the actin
CC       cytoskeleton. {ECO:0000250|UniProtKB:P67966}.
CC   -!- DOMAIN: Glycine-rich repeats mediate the association with the actin
CC       cytoskeleton. {ECO:0000305}.
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DR   EMBL; Z28333; CAA82187.1; -; mRNA.
DR   PIR; S38879; S38879.
DR   RefSeq; XP_015740342.1; XM_015884856.1.
DR   RefSeq; XP_015740344.1; XM_015884858.1.
DR   AlphaFoldDB; P67967; -.
DR   SMR; P67967; -.
DR   Ensembl; ENSCJPT00005013423; ENSCJPP00005008922; ENSCJPG00005007905.
DR   GeneID; 107324658; -.
DR   KEGG; cjo:107324658; -.
DR   CTD; 1465; -.
DR   GeneTree; ENSGT00940000156777; -.
DR   OrthoDB; 1214165at2759; -.
DR   Proteomes; UP000694412; Chromosome 26.
DR   GO; GO:0031252; C:cell leading edge; ISS:AgBase.
DR   GO; GO:0005737; C:cytoplasm; ISS:AgBase.
DR   GO; GO:0005925; C:focal adhesion; ISS:AgBase.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0001725; C:stress fiber; ISS:AgBase.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR001781; Znf_LIM.
DR   Pfam; PF00412; LIM; 2.
DR   SMART; SM00132; LIM; 2.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; LIM domain; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Zinc.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..192
FT                   /note="Cysteine and glycine-rich protein 1"
FT                   /id="PRO_0000075720"
FT   DOMAIN          10..61
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          118..169
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   MOTIF           64..69
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   192 AA;  20385 MW;  43D3D301938BBCE3 CRC64;
     MPNWGGGKKC GVCQKAVYFA EEVQCEGSSF HKSCFLCMVC KKNLDSTTVA VHGDEIYCKS
     CYGKKYGPKG YGYGMGAGTL STDKGESLGI KYEEGQSHRP TNPNASRMAQ KVGGSDGCPR
     CGQAVYAAEK VIGAGKSWHK SCFRCAKCGK SLESTTLADK DGEIYCKGCY AKNFGPKGFG
     FGQGAGALIH SQ