ID   CSRP2_CHICK             Reviewed;         194 AA.
AC   P50460;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Cysteine and glycine-rich protein 2;
DE   AltName: Full=Beta-cysteine-rich protein;
DE            Short=Beta-CRP;
DE   AltName: Full=Cysteine-rich protein 2;
DE            Short=CRP2;
GN   Name=CSRP2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryonic fibroblast;
RX   PubMed=7499425; DOI=10.1074/jbc.270.48.28946;
RA   Weiskirchen R., Pino J.D., Macalma T., Bister K., Beckerle M.C.;
RT   "The cysteine-rich protein family of highly related LIM domain proteins.";
RL   J. Biol. Chem. 270:28946-28954(1995).
CC   -!- FUNCTION: Totally down-regulated in transformed cells. May therefore
CC       take part in the control of cell growth and differentiation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; X84264; CAA59025.1; -; mRNA.
DR   PIR; S52335; S52335.
DR   RefSeq; NP_990539.1; NM_205208.1.
DR   AlphaFoldDB; P50460; -.
DR   SMR; P50460; -.
DR   STRING; 9031.ENSGALP00000043387; -.
DR   PaxDb; P50460; -.
DR   GeneID; 396128; -.
DR   KEGG; gga:396128; -.
DR   CTD; 1466; -.
DR   VEuPathDB; HostDB:geneid_396128; -.
DR   eggNOG; KOG1700; Eukaryota.
DR   HOGENOM; CLU_054591_1_0_1; -.
DR   InParanoid; P50460; -.
DR   PhylomeDB; P50460; -.
DR   TreeFam; TF313758; -.
DR   PRO; PR:P50460; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR   GO; GO:0042805; F:actinin binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008307; F:structural constituent of muscle; IBA:GO_Central.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0060537; P:muscle tissue development; IBA:GO_Central.
DR   GO; GO:0045214; P:sarcomere organization; IBA:GO_Central.
DR   InterPro; IPR001781; Znf_LIM.
DR   Pfam; PF00412; LIM; 2.
DR   SMART; SM00132; LIM; 2.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; LIM domain; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Zinc.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..194
FT                   /note="Cysteine and glycine-rich protein 2"
FT                   /id="PRO_0000075724"
FT   DOMAIN          10..61
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          120..171
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   MOTIF           64..69
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   194 AA;  20925 MW;  C82CCD2084D577DB CRC64;
     MPNWGGGNKC GACGRTVYHA EEVQCDGRSF HRCCFLCMVC RKNLDSTTVA IHDAEVYCKS
     CYGKKYGPKG YGYGQGAGTL NMDRGERLGI KPESTPSPHR PTTNPNTSKF AQKFGGAEKC
     SRCGDSVYAA EKVIGAGKPW HKNCFRCAKC GKSLESTTLT EKEGEIYCKG CYAKNFGPKG
     FGYGQGAGAL VHAQ