CSS3_YEAST
ID CSS3_YEAST Reviewed; 171 AA.
AC Q08300; D6W1R1;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Secreted protein CSS3 {ECO:0000303|PubMed:26928762};
DE AltName: Full=Condition specific secretion protein 3 {ECO:0000303|PubMed:26928762};
DE Flags: Precursor;
GN Name=CSS3 {ECO:0000303|PubMed:26928762}; OrderedLocusNames=YOL159C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169874;
RA Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL Nature 387:98-102(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP SUBCELLULAR LOCATION.
RX PubMed=11935221; DOI=10.1007/s00294-001-0264-9;
RA Terashima H., Fukuchi S., Nakai K., Arisawa M., Hamada K., Yabuki N.,
RA Kitada K.;
RT "Sequence-based approach for identification of cell wall proteins in
RT Saccharomyces cerevisiae.";
RL Curr. Genet. 40:311-316(2002).
RN [4]
RP DISRUPTION PHENOTYPE.
RX PubMed=12871900; DOI=10.1093/genetics/164.3.867;
RA Griffith J.L., Coleman L.E., Raymond A.S., Goodson S.G., Pittard W.S.,
RA Tsui C., Devine S.E.;
RT "Functional genomics reveals relationships between the retrovirus-like Ty1
RT element and its host Saccharomyces cerevisiae.";
RL Genetics 164:867-879(2003).
RN [5]
RP SUBCELLULAR LOCATION.
RX PubMed=26928762; DOI=10.1038/nmeth.3795;
RA Yofe I., Weill U., Meurer M., Chuartzman S., Zalckvar E., Goldman O.,
RA Ben-Dor S., Schuetze C., Wiedemann N., Knop M., Khmelinskii A.,
RA Schuldiner M.;
RT "One library to make them all: streamlining the creation of yeast libraries
RT via a SWAp-Tag strategy.";
RL Nat. Methods 13:371-378(2016).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:11935221}. Secreted
CC {ECO:0000269|PubMed:26928762}.
CC -!- DISRUPTION PHENOTYPE: Leads to elevated levels of Ty1
CC retrotransposition and Ty1 cDNA. {ECO:0000269|PubMed:12871900}.
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DR EMBL; Z74901; CAA99181.1; -; Genomic_DNA.
DR EMBL; BK006948; DAA10627.1; -; Genomic_DNA.
DR PIR; S66858; S66858.
DR RefSeq; NP_014483.1; NM_001183412.1.
DR AlphaFoldDB; Q08300; -.
DR BioGRID; 34259; 36.
DR DIP; DIP-4200N; -.
DR IntAct; Q08300; 1.
DR STRING; 4932.YOL159C; -.
DR PaxDb; Q08300; -.
DR PRIDE; Q08300; -.
DR EnsemblFungi; YOL159C_mRNA; YOL159C; YOL159C.
DR GeneID; 854006; -.
DR KEGG; sce:YOL159C; -.
DR SGD; S000005519; CSS3.
DR VEuPathDB; FungiDB:YOL159C; -.
DR HOGENOM; CLU_133431_0_0_1; -.
DR InParanoid; Q08300; -.
DR OMA; YNGSEPY; -.
DR BioCyc; YEAST:G3O-33547-MON; -.
DR PRO; PR:Q08300; -.
DR Proteomes; UP000002311; Chromosome XV.
DR RNAct; Q08300; protein.
DR GO; GO:0071944; C:cell periphery; HDA:SGD.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; HDA:SGD.
PE 3: Inferred from homology;
KW Cytoplasm; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..171
FT /note="Secreted protein CSS3"
FT /id="PRO_0000245276"
FT CARBOHYD 37
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 139
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 171 AA; 19574 MW; 62AF57C732FB598A CRC64;
MVPLFGLFCI FSQLYSLCSA YVDITSGYQV FFNLPTNMTN NQICWLFQAS YYDIYSDKSG
RTLRTGRFEP GDQQSLIYRD TLVELEAITD SYEYSNLDLS TYNGPEPYNS ETDYCTDIMD
LVMRVYDEEG HYVHPVANNS TNACAHPTPP TLNNLLISNY SDGRNYKESS I
