CST11_HUMAN
ID CST11_HUMAN Reviewed; 138 AA.
AC Q9H112; Q0VAF2; Q0VAF3; Q8WXU5; Q8WXU6; Q9H113;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 2.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Cystatin-11;
DE Flags: Precursor;
GN Name=CST11; Synonyms=CST8L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR
RP LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=12072414; DOI=10.1210/endo.143.7.8925;
RA Hamil K.G., Liu Q., Sivashanmugam P., Yenugu S., Soundararajan R.,
RA Grossman G., Richardson R.T., Zhang Y.-L., O'Rand M.G., Petrusz P.,
RA French F.S., Hall S.H.;
RT "Cystatin 11: a new member of the cystatin type 2 family.";
RL Endocrinology 143:2787-2796(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Has antibacterial activity against the Gram-negative bacteria
CC E.coli. May play a role in sperm maturation and fertilization.
CC {ECO:0000269|PubMed:12072414}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:12072414}.
CC Note=Probably secreted into the epididymis lumen, where it localizes to
CC the outer surface of sperm. Specifically localizes to the postacrosomal
CC and tail regions of sperm. {ECO:0000269|PubMed:12072414}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9H112-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H112-2; Sequence=VSP_001260;
CC -!- TISSUE SPECIFICITY: Detected in the epithelium and lumen of the
CC epididymis, and in sperm (at protein level).
CC {ECO:0000269|PubMed:12072414}.
CC -!- SIMILARITY: Belongs to the cystatin family. {ECO:0000305}.
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DR EMBL; AF335480; AAL71991.1; -; mRNA.
DR EMBL; AF335481; AAL71992.1; -; mRNA.
DR EMBL; AL096677; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471133; EAX10146.1; -; Genomic_DNA.
DR EMBL; BC121079; AAI21080.1; -; mRNA.
DR EMBL; BC121080; AAI21081.1; -; mRNA.
DR CCDS; CCDS13154.1; -. [Q9H112-2]
DR CCDS; CCDS13155.1; -. [Q9H112-1]
DR RefSeq; NP_543020.2; NM_080830.2. [Q9H112-2]
DR RefSeq; NP_570612.1; NM_130794.1. [Q9H112-1]
DR AlphaFoldDB; Q9H112; -.
DR SMR; Q9H112; -.
DR BioGRID; 126748; 97.
DR STRING; 9606.ENSP00000366208; -.
DR MEROPS; I25.027; -.
DR GlyGen; Q9H112; 1 site.
DR iPTMnet; Q9H112; -.
DR PhosphoSitePlus; Q9H112; -.
DR BioMuta; CST11; -.
DR DMDM; 76803548; -.
DR MassIVE; Q9H112; -.
DR PaxDb; Q9H112; -.
DR PeptideAtlas; Q9H112; -.
DR PRIDE; Q9H112; -.
DR Antibodypedia; 54198; 90 antibodies from 16 providers.
DR DNASU; 140880; -.
DR Ensembl; ENST00000377007.3; ENSP00000366206.3; ENSG00000125831.10. [Q9H112-2]
DR Ensembl; ENST00000377009.8; ENSP00000366208.3; ENSG00000125831.10. [Q9H112-1]
DR GeneID; 140880; -.
DR KEGG; hsa:140880; -.
DR MANE-Select; ENST00000377009.8; ENSP00000366208.3; NM_130794.2; NP_570612.1.
DR UCSC; uc002wtf.2; human. [Q9H112-1]
DR CTD; 140880; -.
DR DisGeNET; 140880; -.
DR GeneCards; CST11; -.
DR HGNC; HGNC:15959; CST11.
DR HPA; ENSG00000125831; Tissue enriched (epididymis).
DR MIM; 609731; gene.
DR neXtProt; NX_Q9H112; -.
DR OpenTargets; ENSG00000125831; -.
DR PharmGKB; PA26974; -.
DR VEuPathDB; HostDB:ENSG00000125831; -.
DR eggNOG; ENOG502RWFM; Eukaryota.
DR GeneTree; ENSGT00910000144356; -.
DR HOGENOM; CLU_118168_2_1_1; -.
DR InParanoid; Q9H112; -.
DR OMA; ETTNCVP; -.
DR OrthoDB; 1565344at2759; -.
DR PhylomeDB; Q9H112; -.
DR PathwayCommons; Q9H112; -.
DR BioGRID-ORCS; 140880; 10 hits in 1066 CRISPR screens.
DR GeneWiki; CST11; -.
DR GenomeRNAi; 140880; -.
DR Pharos; Q9H112; Tbio.
DR PRO; PR:Q9H112; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9H112; protein.
DR Bgee; ENSG00000125831; Expressed in corpus epididymis and 54 other tissues.
DR ExpressionAtlas; Q9H112; baseline and differential.
DR Genevisible; Q9H112; HS.
DR GO; GO:0005737; C:cytoplasm; IMP:UniProtKB.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IMP:UniProtKB.
DR GO; GO:0036126; C:sperm flagellum; IDA:UniProtKB.
DR GO; GO:0061827; C:sperm head; IDA:UniProtKB.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0030521; P:androgen receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR GO; GO:0031640; P:killing of cells of another organism; IDA:UniProtKB.
DR CDD; cd00042; CY; 1.
DR InterPro; IPR042930; CST11.
DR InterPro; IPR000010; Cystatin_dom.
DR InterPro; IPR046350; Cystatin_sf.
DR PANTHER; PTHR47886; PTHR47886; 1.
DR Pfam; PF00031; Cystatin; 1.
DR SMART; SM00043; CY; 1.
DR SUPFAM; SSF54403; SSF54403; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Antibiotic; Antimicrobial; Disulfide bond;
KW Glycoprotein; Protease inhibitor; Reference proteome; Secreted; Signal;
KW Thiol protease inhibitor.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..138
FT /note="Cystatin-11"
FT /id="PRO_0000006658"
FT CARBOHYD 132
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 94..102
FT /evidence="ECO:0000250|UniProtKB:O76096"
FT DISULFID 115..135
FT /evidence="ECO:0000250|UniProtKB:O76096"
FT VAR_SEQ 77..111
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12072414,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_001260"
SQ SEQUENCE 138 AA; 16506 MW; E49440ACA3585C64 CRC64;
MMAEPWQALQ LLLAILLTLM ALPYQARKKT FLSVHEVMAV ENYAKDSLQW ITDQYNKESD
DKYHFRIFRV LKVQRQVTDH LEYHLNVEMQ WTTCQKPETT NCVPQERELH KQVNCFFSVF
AVPWFEQYKI LNKSCSSD
