CST11_RAT
ID CST11_RAT Reviewed; 139 AA.
AC Q8K5A3;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Cystatin-11;
DE Flags: Precursor;
GN Name=Cst11;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley;
RA Hamil K.G., Hall S.H.;
RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Has antibacterial activity against the Gram-negative bacteria
CC E.coli. May play a role in sperm maturation and fertilization.
CC {ECO:0000250|UniProtKB:Q9H112}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9H112}.
CC Note=Probably secreted into the epididymis lumen, where it localizes to
CC the outer surface of sperm. Specifically localizes to the postacrosomal
CC and tail regions of sperm. {ECO:0000250|UniProtKB:Q9H112}.
CC -!- SIMILARITY: Belongs to the cystatin family. {ECO:0000305}.
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DR EMBL; AF501290; AAM21709.1; -; mRNA.
DR RefSeq; NP_620785.1; NM_139085.1.
DR AlphaFoldDB; Q8K5A3; -.
DR SMR; Q8K5A3; -.
DR STRING; 10116.ENSRNOP00000006427; -.
DR GlyGen; Q8K5A3; 1 site.
DR PaxDb; Q8K5A3; -.
DR Ensembl; ENSRNOT00000006427; ENSRNOP00000006427; ENSRNOG00000004808.
DR GeneID; 245916; -.
DR KEGG; rno:245916; -.
DR UCSC; RGD:620589; rat.
DR CTD; 140880; -.
DR RGD; 620589; Cst11.
DR eggNOG; ENOG502RWFM; Eukaryota.
DR GeneTree; ENSGT00910000144356; -.
DR HOGENOM; CLU_118168_2_1_1; -.
DR InParanoid; Q8K5A3; -.
DR OMA; ETTNCVP; -.
DR OrthoDB; 1565344at2759; -.
DR PhylomeDB; Q8K5A3; -.
DR PRO; PR:Q8K5A3; -.
DR Proteomes; UP000002494; Chromosome 3.
DR Bgee; ENSRNOG00000004808; Expressed in testis.
DR Genevisible; Q8K5A3; RN.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0036126; C:sperm flagellum; ISS:UniProtKB.
DR GO; GO:0061827; C:sperm head; ISS:UniProtKB.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0030521; P:androgen receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; ISS:UniProtKB.
DR GO; GO:0031640; P:killing of cells of another organism; ISS:UniProtKB.
DR CDD; cd00042; CY; 1.
DR InterPro; IPR042930; CST11.
DR InterPro; IPR000010; Cystatin_dom.
DR InterPro; IPR046350; Cystatin_sf.
DR PANTHER; PTHR47886; PTHR47886; 1.
DR Pfam; PF00031; Cystatin; 1.
DR SMART; SM00043; CY; 1.
DR SUPFAM; SSF54403; SSF54403; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Protease inhibitor; Reference proteome;
KW Secreted; Signal; Thiol protease inhibitor.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..139
FT /note="Cystatin-11"
FT /id="PRO_0000006660"
FT CARBOHYD 134
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 94..102
FT /evidence="ECO:0000250|UniProtKB:O76096"
FT DISULFID 115..135
FT /evidence="ECO:0000250|UniProtKB:O76096"
SQ SEQUENCE 139 AA; 16686 MW; E1E36DB786B4D08C CRC64;
MMARLWKTTW FLLAILVALV AFSYQVKRKT FIRVEEVNAL ESSVKETLEY VTEEYNKKSE
DLYNFRILRI LKIEKQMTNH MEFHITVEMQ RTTCLKTEKN LCNVQEGELH KQIQCYFSVY
VIPWLEVFKM LKKNCTNSS
