ID   CST12_RAT               Reviewed;         128 AA.
AC   Q8VII2;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Cystatin-12;
DE   AltName: Full=Cystatin TE-1;
DE   Flags: Precursor;
GN   Name=Cst12;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Testis;
RX   PubMed=12444065; DOI=10.1095/biolreprod.102.003368;
RA   Li Y., Friel P.J., Robinson M.O., McLean D.J., Griswold M.D.;
RT   "Identification and characterization of testis- and epididymis-specific
RT   genes: cystatin SC and cystatin TE-1.";
RL   Biol. Reprod. 67:1872-1880(2002).
CC   -!- FUNCTION: May play a specialized role in spermatogenesis.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cystatin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF440736; AAL30842.1; -; mRNA.
DR   RefSeq; NP_714956.1; NM_153734.1.
DR   AlphaFoldDB; Q8VII2; -.
DR   SMR; Q8VII2; -.
DR   STRING; 10116.ENSRNOP00000006608; -.
DR   GlyGen; Q8VII2; 1 site.
DR   PhosphoSitePlus; Q8VII2; -.
DR   PaxDb; Q8VII2; -.
DR   GeneID; 266776; -.
DR   KEGG; rno:266776; -.
DR   UCSC; RGD:708514; rat.
DR   CTD; 69362; -.
DR   RGD; 708514; Cst12.
DR   eggNOG; ENOG502TDK9; Eukaryota.
DR   InParanoid; Q8VII2; -.
DR   OrthoDB; 1565344at2759; -.
DR   PhylomeDB; Q8VII2; -.
DR   PRO; PR:Q8VII2; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd00042; CY; 1.
DR   InterPro; IPR000010; Cystatin_dom.
DR   InterPro; IPR046350; Cystatin_sf.
DR   Pfam; PF00031; Cystatin; 1.
DR   SUPFAM; SSF54403; SSF54403; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Protease inhibitor; Reference proteome;
KW   Secreted; Signal; Thiol protease inhibitor.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..128
FT                   /note="Cystatin-12"
FT                   /id="PRO_0000285792"
FT   CARBOHYD        122
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        82..92
FT                   /evidence="ECO:0000250"
FT   DISULFID        105..125
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   128 AA;  15152 MW;  BC158982F5EDA535 CRC64;
     MLWKSVLPVA LIVLGIHDCS FKFIEIDKNE EEFAMSMEHV LFHFNENQND DFAYKFLRVR
     RSLRKKYTQK YLVDLEMGRT LCGKYDEDID NCPLQEGPGE KKVRCTYIVE TRVWVTEFTI
     LNSTCVQT