CST14_MOUSE
ID CST14_MOUSE Reviewed; 130 AA.
AC Q8VII3; Q9CX46;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Cystatin-14;
DE AltName: Full=Cystatin SC;
DE Flags: Precursor;
GN Name=Cst14;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=12444065; DOI=10.1095/biolreprod.102.003368;
RA Li Y., Friel P.J., Robinson M.O., McLean D.J., Griswold M.D.;
RT "Identification and characterization of testis- and epididymis-specific
RT genes: cystatin SC and cystatin TE-1.";
RL Biol. Reprod. 67:1872-1880(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a specialized role in spermatogenesis.
CC {ECO:0000269|PubMed:12444065}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Located only in seminiferous tubules (at protein
CC level). Expressed in testis and Sertoli cells.
CC {ECO:0000269|PubMed:12444065}.
CC -!- SIMILARITY: Belongs to the cystatin family. {ECO:0000305}.
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DR EMBL; AF440735; AAL30841.1; -; mRNA.
DR EMBL; AK020193; BAB32024.1; -; mRNA.
DR EMBL; AL844519; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC132218; AAI32219.1; -; mRNA.
DR EMBL; BC132222; AAI32223.1; -; mRNA.
DR CCDS; CCDS16846.1; -.
DR RefSeq; NP_084411.1; NM_030135.2.
DR AlphaFoldDB; Q8VII3; -.
DR SMR; Q8VII3; -.
DR STRING; 10090.ENSMUSP00000028933; -.
DR PaxDb; Q8VII3; -.
DR PRIDE; Q8VII3; -.
DR ProteomicsDB; 285380; -.
DR DNASU; 78609; -.
DR Ensembl; ENSMUST00000028933; ENSMUSP00000028933; ENSMUSG00000027444.
DR GeneID; 78609; -.
DR KEGG; mmu:78609; -.
DR UCSC; uc008mtm.1; mouse.
DR CTD; 78609; -.
DR MGI; MGI:1925859; 8030411F24Rik.
DR VEuPathDB; HostDB:ENSMUSG00000027444; -.
DR eggNOG; ENOG502TDK9; Eukaryota.
DR GeneTree; ENSGT00940000162636; -.
DR HOGENOM; CLU_118168_3_2_1; -.
DR InParanoid; Q8VII3; -.
DR OMA; WTMIFLM; -.
DR OrthoDB; 1565344at2759; -.
DR PhylomeDB; Q8VII3; -.
DR BioGRID-ORCS; 78609; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q8VII3; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8VII3; protein.
DR Bgee; ENSMUSG00000027444; Expressed in morula and 11 other tissues.
DR Genevisible; Q8VII3; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd00042; CY; 1.
DR InterPro; IPR000010; Cystatin_dom.
DR InterPro; IPR046350; Cystatin_sf.
DR Pfam; PF00031; Cystatin; 1.
DR SMART; SM00043; CY; 1.
DR SUPFAM; SSF54403; SSF54403; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Protease inhibitor; Reference proteome; Secreted; Signal;
KW Thiol protease inhibitor.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..130
FT /note="Cystatin-14"
FT /id="PRO_0000285793"
FT DISULFID 84..94
FT /evidence="ECO:0000250"
FT DISULFID 107..127
FT /evidence="ECO:0000250"
FT CONFLICT 3
FT /note="W -> G (in Ref. 2; BAB32024)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 130 AA; 15077 MW; DD34930B64AFE58F CRC64;
MSWKVPMLVG LVVLGTHIWT INKEFLDVTK DLDYFVASVE FAVAQFNDNN PEENTYKLLE
VGRAQKKTWT MIFLMDLEMG RTICKKHDEN IHNCPLLQGS REKKVHCVFQ VDARPWFSHF
TILTSTCVPT
