ID   CST9_BOVIN              Reviewed;         153 AA.
AC   Q29RH0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Cystatin-9;
DE   Flags: Precursor;
GN   Name=CST9;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in hematopoietic differentiation or
CC       inflammation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Note=May be targeted through the Golgi
CC       via the secretory pathway. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cystatin family. {ECO:0000305}.
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DR   EMBL; BC114179; AAI14180.1; -; mRNA.
DR   RefSeq; NP_001039372.1; NM_001045907.2.
DR   AlphaFoldDB; Q29RH0; -.
DR   SMR; Q29RH0; -.
DR   STRING; 9913.ENSBTAP00000011269; -.
DR   PaxDb; Q29RH0; -.
DR   GeneID; 505033; -.
DR   KEGG; bta:505033; -.
DR   eggNOG; ENOG502TAJ0; Eukaryota.
DR   InParanoid; Q29RH0; -.
DR   OrthoDB; 1577727at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0019730; P:antimicrobial humoral response; IBA:GO_Central.
DR   CDD; cd00042; CY; 1.
DR   InterPro; IPR043250; CST9-like.
DR   InterPro; IPR000010; Cystatin_dom.
DR   InterPro; IPR046350; Cystatin_sf.
DR   PANTHER; PTHR46945; PTHR46945; 1.
DR   Pfam; PF00031; Cystatin; 1.
DR   SUPFAM; SSF54403; SSF54403; 1.
PE   2: Evidence at transcript level;
KW   Protease inhibitor; Reference proteome; Secreted; Signal;
KW   Thiol protease inhibitor.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..153
FT                   /note="Cystatin-9"
FT                   /id="PRO_0000314692"
SQ   SEQUENCE   153 AA;  17950 MW;  8A55AC36DF948E92 CRC64;
     MGRQRRCRWA QPWTLLLLLL GPRLLVTHGW RRKGDKNSEN TNILELYLPA VVEYALHVYN
     MRSQDMNAYK VVRVLRSWLE LSEQKEEKGL VFSMELQFAR TRCGKFDEDI DNCPFQATPD
     VNNTITCFFT VDTEPWKTEF QLLNDTCLEG SAE