ID   CSTA_AQUAE              Reviewed;         555 AA.
AC   O67304;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Peptide transporter CstA {ECO:0000305};
DE   AltName: Full=Carbon starvation protein A homolog {ECO:0000305};
GN   Name=cstA; OrderedLocusNames=aq_1265;
OS   Aquifex aeolicus (strain VF5).
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=224324;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VF5;
RX   PubMed=9537320; DOI=10.1038/32831;
RA   Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA   Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA   Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT   "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL   Nature 392:353-358(1998).
CC   -!- FUNCTION: Involved in peptide utilization.
CC       {ECO:0000250|UniProtKB:P15078}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the peptide transporter carbon starvation (CstA)
CC       (TC 2.A.114) family. {ECO:0000305}.
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DR   EMBL; AE000657; AAC07258.1; -; Genomic_DNA.
DR   PIR; E70409; E70409.
DR   RefSeq; NP_213868.1; NC_000918.1.
DR   RefSeq; WP_010880806.1; NC_000918.1.
DR   AlphaFoldDB; O67304; -.
DR   STRING; 224324.aq_1265; -.
DR   EnsemblBacteria; AAC07258; AAC07258; aq_1265.
DR   KEGG; aae:aq_1265; -.
DR   PATRIC; fig|224324.8.peg.986; -.
DR   eggNOG; COG1966; Bacteria.
DR   HOGENOM; CLU_010531_4_1_0; -.
DR   InParanoid; O67304; -.
DR   OMA; GTISGFH; -.
DR   OrthoDB; 457782at2; -.
DR   Proteomes; UP000000798; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0031669; P:cellular response to nutrient levels; IBA:GO_Central.
DR   GO; GO:0009267; P:cellular response to starvation; IEA:InterPro.
DR   GO; GO:0015833; P:peptide transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR025299; CstA_C.
DR   InterPro; IPR003706; CstA_N.
DR   Pfam; PF02554; CstA; 1.
DR   Pfam; PF13722; CstA_5TM; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Peptide transport; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..555
FT                   /note="Peptide transporter CstA"
FT                   /id="PRO_0000190044"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        251..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        290..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        327..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        388..408
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        433..453
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        462..482
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        494..514
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        523..543
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   555 AA;  60114 MW;  B3BC690C460E7F04 CRC64;
     MHALPLIGIA FLLYAFGYFV YSKYLAEKIF QLDDSRPTPA KEINDGVDYV PTNKWILLGH
     HFTSITGAGP IVGPAIAVIW GWLPAFLWVV LGAVFIGGVH DFTALVTSIR HKGKSIGTIL
     GEYAGEKARV LFLLLLLALA ILVNAVFAYV ISLLFVKYPS SVLPAWLVIP LAVIFGFSVY
     RLRVNFLILT VIFLSILYFG IYLGSVSPID VKPLAESLGL SPIMLWIIVL FTYAFFASSL
     PVWVLLQPRD FLNGLQLLIL LILLYIGAVI ANPKIVAPAV NLNPEGAPPI FPFLFITIAC
     GALSGFHALV SSGTSSKQLE KESDARAVGY LGFMGESSLA LAVIIATTAG IAMFSAEKFQ
     ELYSSWSSIK SSSLVAVVDG GANLLGAVGI PVDFGKTVIA TLVVLFAATT MDTSVRIQRY
     ILGELGEIYG VRLLTNPWVA SGVAVLTSMA LVLSKEGGKG GMVFWPVFGA ANQLLAGLAL
     LIGYLYLKRV NRPTLPILIP MIFVLFITSL AMAMNAWNNL MKGDLLLFSV SFIILLLEMF
     IIFESFRAVR RAPAF