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CSTA_BACSU
ID   CSTA_BACSU              Reviewed;         598 AA.
AC   P94532;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 2.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Peptide transporter CstA {ECO:0000305};
DE   AltName: Full=Carbon starvation protein A homolog {ECO:0000305};
GN   Name=cstA; OrderedLocusNames=BSU28710;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=8969504; DOI=10.1099/13500872-142-11-3067;
RA   Wipat A., Carter N., Brignell C.S., Guy J.B., Piper K., Sanders J.,
RA   Emmerson P.T., Harwood C.R.;
RT   "The dnaB-pheA (256 degrees-240 degrees) region of the Bacillus subtilis
RT   chromosome containing genes responsible for stress responses, the
RT   utilization of plant cell walls and primary metabolism.";
RL   Microbiology 142:3067-3078(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   SEQUENCE REVISION TO 497.
RX   PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA   Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA   Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT   "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT   168 reference genome a decade later.";
RL   Microbiology 155:1758-1775(2009).
CC   -!- FUNCTION: Involved in peptide utilization.
CC       {ECO:0000250|UniProtKB:P15078}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the peptide transporter carbon starvation (CstA)
CC       (TC 2.A.114) family. {ECO:0000305}.
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DR   EMBL; Z75208; CAA99596.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB14831.2; -; Genomic_DNA.
DR   PIR; A69609; A69609.
DR   RefSeq; NP_390749.2; NC_000964.3.
DR   RefSeq; WP_003229512.1; NZ_JNCM01000036.1.
DR   AlphaFoldDB; P94532; -.
DR   IntAct; P94532; 1.
DR   STRING; 224308.BSU28710; -.
DR   PaxDb; P94532; -.
DR   PRIDE; P94532; -.
DR   EnsemblBacteria; CAB14831; CAB14831; BSU_28710.
DR   GeneID; 937970; -.
DR   KEGG; bsu:BSU28710; -.
DR   PATRIC; fig|224308.179.peg.3119; -.
DR   eggNOG; COG1966; Bacteria.
DR   InParanoid; P94532; -.
DR   OMA; GTISGFH; -.
DR   PhylomeDB; P94532; -.
DR   BioCyc; BSUB:BSU28710-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0031669; P:cellular response to nutrient levels; IBA:GO_Central.
DR   GO; GO:0009267; P:cellular response to starvation; IEA:InterPro.
DR   GO; GO:0015833; P:peptide transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR025299; CstA_C.
DR   InterPro; IPR003706; CstA_N.
DR   Pfam; PF02554; CstA; 1.
DR   Pfam; PF13722; CstA_5TM; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Peptide transport; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..598
FT                   /note="Peptide transporter CstA"
FT                   /id="PRO_0000190045"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        254..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        328..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        391..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        414..434
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        461..481
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        488..508
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        521..541
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        557..577
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        497
FT                   /note="Q -> R (in Ref. 1; CAA99596)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   598 AA;  64333 MW;  A81C1180802433F4 CRC64;
     MNAVTIVIAS MCILAIAYRL YGTFMMVKVL KVNDDKPTPA HALEDGKDYV PTNKWVSFGH
     HFAAIAAAGP LVGPILAAQF GYLPGLLWLL IGAVIGGAVH DIVVLFASMR KNGKSLSEVA
     KDELGPVAGF CTGLSMLFII TITMAGLSMV VLHALERNPW GTFAVGITIP IAMGVGLFYK
     KTGNLKLAST VGFLFLMAGV FIGPWVQTTA LGDFLTLDTK TLAIALPVYA FFAAALPVWL
     LLAPRDYLSS FMKIGVFIAL IVGVFVVNPS IPFPAFTEFV KGGGPVLAGP VWPFISITIA
     CGAISGFHAF VGSGTTPKML NKWSDMKPVA FGAMLVECLV GIMALIAATA LQPADYFAIN
     STPEVFRTLG MNVVHLPELS GEIGLDLEGR TGGAVTLAVG MTYIFTGMPF FSHLASYFFQ
     FVIMFEAVFI LTAIDAGTRV ARYLIQDFFG EVYKPLKKTD WIPGSVFASA LACLMWGYLL
     YSGDIGSIWA LFGVSNQLMA SVGLIIGATI VLKIADKRRY ILTCLIPLAY LYVTVNYAGY
     WMVRNVYLNP EAAGYSVLNG VLSIIMLVLG FIIIVAAVKK WAQMWKDPSL RMEASIPG
 
 
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