CSTA_BACSU
ID CSTA_BACSU Reviewed; 598 AA.
AC P94532;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 07-JUL-2009, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Peptide transporter CstA {ECO:0000305};
DE AltName: Full=Carbon starvation protein A homolog {ECO:0000305};
GN Name=cstA; OrderedLocusNames=BSU28710;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=8969504; DOI=10.1099/13500872-142-11-3067;
RA Wipat A., Carter N., Brignell C.S., Guy J.B., Piper K., Sanders J.,
RA Emmerson P.T., Harwood C.R.;
RT "The dnaB-pheA (256 degrees-240 degrees) region of the Bacillus subtilis
RT chromosome containing genes responsible for stress responses, the
RT utilization of plant cell walls and primary metabolism.";
RL Microbiology 142:3067-3078(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP SEQUENCE REVISION TO 497.
RX PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT 168 reference genome a decade later.";
RL Microbiology 155:1758-1775(2009).
CC -!- FUNCTION: Involved in peptide utilization.
CC {ECO:0000250|UniProtKB:P15078}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the peptide transporter carbon starvation (CstA)
CC (TC 2.A.114) family. {ECO:0000305}.
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DR EMBL; Z75208; CAA99596.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB14831.2; -; Genomic_DNA.
DR PIR; A69609; A69609.
DR RefSeq; NP_390749.2; NC_000964.3.
DR RefSeq; WP_003229512.1; NZ_JNCM01000036.1.
DR AlphaFoldDB; P94532; -.
DR IntAct; P94532; 1.
DR STRING; 224308.BSU28710; -.
DR PaxDb; P94532; -.
DR PRIDE; P94532; -.
DR EnsemblBacteria; CAB14831; CAB14831; BSU_28710.
DR GeneID; 937970; -.
DR KEGG; bsu:BSU28710; -.
DR PATRIC; fig|224308.179.peg.3119; -.
DR eggNOG; COG1966; Bacteria.
DR InParanoid; P94532; -.
DR OMA; GTISGFH; -.
DR PhylomeDB; P94532; -.
DR BioCyc; BSUB:BSU28710-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0031669; P:cellular response to nutrient levels; IBA:GO_Central.
DR GO; GO:0009267; P:cellular response to starvation; IEA:InterPro.
DR GO; GO:0015833; P:peptide transport; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR025299; CstA_C.
DR InterPro; IPR003706; CstA_N.
DR Pfam; PF02554; CstA; 1.
DR Pfam; PF13722; CstA_5TM; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Peptide transport; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..598
FT /note="Peptide transporter CstA"
FT /id="PRO_0000190045"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 328..348
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 391..411
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 414..434
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 461..481
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 488..508
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 521..541
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 557..577
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 497
FT /note="Q -> R (in Ref. 1; CAA99596)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 598 AA; 64333 MW; A81C1180802433F4 CRC64;
MNAVTIVIAS MCILAIAYRL YGTFMMVKVL KVNDDKPTPA HALEDGKDYV PTNKWVSFGH
HFAAIAAAGP LVGPILAAQF GYLPGLLWLL IGAVIGGAVH DIVVLFASMR KNGKSLSEVA
KDELGPVAGF CTGLSMLFII TITMAGLSMV VLHALERNPW GTFAVGITIP IAMGVGLFYK
KTGNLKLAST VGFLFLMAGV FIGPWVQTTA LGDFLTLDTK TLAIALPVYA FFAAALPVWL
LLAPRDYLSS FMKIGVFIAL IVGVFVVNPS IPFPAFTEFV KGGGPVLAGP VWPFISITIA
CGAISGFHAF VGSGTTPKML NKWSDMKPVA FGAMLVECLV GIMALIAATA LQPADYFAIN
STPEVFRTLG MNVVHLPELS GEIGLDLEGR TGGAVTLAVG MTYIFTGMPF FSHLASYFFQ
FVIMFEAVFI LTAIDAGTRV ARYLIQDFFG EVYKPLKKTD WIPGSVFASA LACLMWGYLL
YSGDIGSIWA LFGVSNQLMA SVGLIIGATI VLKIADKRRY ILTCLIPLAY LYVTVNYAGY
WMVRNVYLNP EAAGYSVLNG VLSIIMLVLG FIIIVAAVKK WAQMWKDPSL RMEASIPG