CSTA_HELPY
ID CSTA_HELPY Reviewed; 687 AA.
AC P56190;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Peptide transporter CstA {ECO:0000305};
DE AltName: Full=Carbon starvation protein A homolog {ECO:0000305};
GN Name=cstA; OrderedLocusNames=HP_1168;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
CC -!- FUNCTION: Involved in peptide utilization.
CC {ECO:0000250|UniProtKB:P15078}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the peptide transporter carbon starvation (CstA)
CC (TC 2.A.114) family. {ECO:0000305}.
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DR EMBL; AE000511; AAD08212.1; -; Genomic_DNA.
DR PIR; H64665; H64665.
DR RefSeq; NP_207959.1; NC_000915.1.
DR RefSeq; WP_001172668.1; NC_018939.1.
DR AlphaFoldDB; P56190; -.
DR IntAct; P56190; 2.
DR MINT; P56190; -.
DR STRING; 85962.C694_06035; -.
DR PaxDb; P56190; -.
DR EnsemblBacteria; AAD08212; AAD08212; HP_1168.
DR KEGG; hpy:HP_1168; -.
DR PATRIC; fig|85962.47.peg.1255; -.
DR eggNOG; COG1966; Bacteria.
DR OMA; GTISGFH; -.
DR PhylomeDB; P56190; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0031669; P:cellular response to nutrient levels; IBA:GO_Central.
DR GO; GO:0009267; P:cellular response to starvation; IEA:InterPro.
DR GO; GO:0015833; P:peptide transport; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR025299; CstA_C.
DR InterPro; IPR003706; CstA_N.
DR Pfam; PF02554; CstA; 1.
DR Pfam; PF13722; CstA_5TM; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Peptide transport;
KW Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..687
FT /note="Peptide transporter CstA"
FT /id="PRO_0000190047"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 256..276
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..305
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..345
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 440..460
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 462..482
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 513..533
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 546..566
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 574..594
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 642..662
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 687 AA; 74205 MW; C525D97653E69C3D CRC64;
MQKSLVSLAW VFVAILGAIC LGVLALHKGE SINTLWLVVA SACIYSIGYR FYSHFIAYKV
LKLDDSRATP ACVRNDGKDF VPTDKAITFG HHFAAIAGAG PLVGPILAAQ MGYLPSILWI
LIGSVLGGCV HDFVVLFASI RRDGKSLGEM IKLEMGQFVG MIASLGILGI MLIIIAILAM
VVVKALAHSP WGFFTIAMTI PIAILMGLYM RFFRPHKILE VSVIGFILLI IAIYAGKYVS
LDPKLASIFT FEASSLAWMI MGYGFVASIL PVWFLLAPRD YLSTFLKIGV IGVLVVAIIF
VAPPLQIPKI TPFVDGSGPV FAGSVFPFLF ITVACGTISG FHALISSGTT PKMLAKESDA
RLVGYGSMVM ESVVALMALV CAGILHPGLY FAINSPEVSI GKDIADAASV ISSWGFNISA
EEIREMTKNI GESSILSRTG GAPTFAIGLA MIVYHILGDP SVMAFWYHFA ILFEALFILT
AVDAGTRTAR FMIQDLLGNV YKPLGDLSSY KAGIFATLLC VAGWGYFLYQ GTIDPKGGIY
TLWPLFGVSN QMLAGMALLL VTVVLFKMGR FKGAMISALP AVLILSITFY SGILKVVPKS
DNSVLNNVSH VAQMQIIKEK MATTTDEKAL KTLQKSFFNH AIDAILCVFF MLVALLVLIV
SVRICSNAYF KNKIYPPLAE TPYIKAS
