ID   CSTA_MYCTU              Reviewed;         758 AA.
AC   P9WP47; L0TBQ3; P95095;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Peptide transporter CstA {ECO:0000305};
DE   AltName: Full=Carbon starvation protein A homolog {ECO:0000305};
GN   Name=cstA; OrderedLocusNames=Rv3063; ORFNames=MTCY22D7.18c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- FUNCTION: Involved in peptide utilization.
CC       {ECO:0000250|UniProtKB:P15078}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the peptide transporter carbon starvation (CstA)
CC       (TC 2.A.114) family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP45872.1; -; Genomic_DNA.
DR   PIR; H70649; H70649.
DR   RefSeq; NP_217579.1; NC_000962.3.
DR   RefSeq; WP_003917116.1; NZ_NVQJ01000011.1.
DR   AlphaFoldDB; P9WP47; -.
DR   STRING; 83332.Rv3063; -.
DR   PaxDb; P9WP47; -.
DR   GeneID; 887948; -.
DR   KEGG; mtu:Rv3063; -.
DR   TubercuList; Rv3063; -.
DR   eggNOG; COG1966; Bacteria.
DR   OMA; GTISGFH; -.
DR   PhylomeDB; P9WP47; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0031669; P:cellular response to nutrient levels; IBA:GO_Central.
DR   GO; GO:0009267; P:cellular response to starvation; IEA:InterPro.
DR   GO; GO:0015833; P:peptide transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR025299; CstA_C.
DR   InterPro; IPR003706; CstA_N.
DR   Pfam; PF02554; CstA; 1.
DR   Pfam; PF13722; CstA_5TM; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Peptide transport; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..758
FT                   /note="Peptide transporter CstA"
FT                   /id="PRO_0000190049"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        361..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        401..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        498..518
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        561..581
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        588..608
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        615..635
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        687..707
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   758 AA;  80163 MW;  D5BC6E0D3668FE10 CRC64;
     MAAPTPSNRI EERSGHASCV RADADLPPVA ILGRSPITLR HKIFFVAVAV IGALAWTVVA
     FFRNEPVNAV WIVVAAGCTY IIGFRFYARL IEMKVVRPRD DHATPAEILD DGTDYVPTDR
     RVVFGHHFAA IAGAGPLVGP VLATQMGYLP SSIWIVVGAV LAGCVQDYLV LWISVRRRGR
     SLGQMVRDEL GATAGVAALV GIPVIITIVI AVLALVVVRA LAKSPWGVFS IAMTIPIAIF
     MGCYLRFLRP GRVSEVSLIG IGLLLLAVVS GDWVAHTSWG AAWFSLSPVT LCWLLISYGF
     AASVLPVWLL LAPRDYLSTF MKVGTIALLA IGVCAAHPII EAPAVSKFAG SGNGPVFAGS
     LFPFLFITIA CGALSGFHAL ICSGTTPKML EKEGQMRVIG YGGMMTESFV AVIALLTAAI
     LDQHLYFTLN APSLHTHDSA ATAAKYVNGL GLTGSPVTPD HISQAAASVG EQTIVSRTGG
     APTLAFGMAE MLHRVVGGVG LKAFWYHFAI MFEALFILTT VDAGTRAARF MISDALGNFG
     GVLRKLQNPS WRPGAWACRL VVVAAWGSIL LLGVTDPLGG INTLFPLFGI ANQLLAGIAL
     TVITVVVIKK GRLKWAWIPG IPLLWDLAVT LTASWQKIFS ADPSVGYWTQ HAHYAAAQHA
     GETAFGSATN ADEINDVVRN TFVQGTLSIV FVVVVVLVVV AGVIVALKTI RGRGIPLAED
     DPAPSTLFAP AGLIPTAAER KLQRRLGAPA SASVAAPD