ID   CSTF1_PONAB             Reviewed;         431 AA.
AC   Q5R8K2;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Cleavage stimulation factor subunit 1;
DE   AltName: Full=Cleavage stimulation factor 50 kDa subunit;
DE            Short=CSTF 50 kDa subunit;
DE            Short=CstF-50;
GN   Name=CSTF1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: One of the multiple factors required for polyadenylation and
CC       3'-end cleavage of mammalian pre-mRNAs (By similarity). May be
CC       responsible for the interaction of CSTF with other factors to form a
CC       stable complex on the pre-mRNA (By similarity).
CC       {ECO:0000250|UniProtKB:Q05048}.
CC   -!- SUBUNIT: Homodimer (By similarity). The CSTF complex is composed of
CC       CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa
CC       subunit) (By similarity). Interacts (via repeats WD) directly with
CC       CSTF3 (By similarity). Interacts (via repeat WD6) with BARD1 (By
CC       similarity). Interacts with ERCC6 (By similarity).
CC       {ECO:0000250|UniProtKB:Q05048}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q05048}.
CC   -!- DOMAIN: N-terminus mediates homodimerization.
CC       {ECO:0000250|UniProtKB:Q05048}.
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DR   EMBL; CR859750; CAH91908.1; -; mRNA.
DR   RefSeq; NP_001127479.1; NM_001134007.1.
DR   AlphaFoldDB; Q5R8K2; -.
DR   SMR; Q5R8K2; -.
DR   STRING; 9601.ENSPPYP00000024472; -.
DR   GeneID; 100174553; -.
DR   KEGG; pon:100174553; -.
DR   CTD; 1477; -.
DR   eggNOG; KOG0640; Eukaryota.
DR   InParanoid; Q5R8K2; -.
DR   OrthoDB; 587820at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005848; C:mRNA cleavage stimulating factor complex; IEA:InterPro.
DR   GO; GO:0031124; P:mRNA 3'-end processing; IEA:InterPro.
DR   Gene3D; 1.20.960.50; -; 1.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR044633; CstF1-like.
DR   InterPro; IPR032028; CSTF1_dimer.
DR   InterPro; IPR038184; CSTF1_dimer_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR44133; PTHR44133; 1.
DR   Pfam; PF16699; CSTF1_dimer; 1.
DR   Pfam; PF00400; WD40; 5.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   mRNA processing; Nucleus; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..431
FT                   /note="Cleavage stimulation factor subunit 1"
FT                   /id="PRO_0000050946"
FT   REPEAT          106..145
FT                   /note="WD 1"
FT   REPEAT          171..210
FT                   /note="WD 2"
FT   REPEAT          215..254
FT                   /note="WD 3"
FT   REPEAT          260..301
FT                   /note="WD 4"
FT   REPEAT          303..343
FT                   /note="WD 5"
FT   REPEAT          395..431
FT                   /note="WD 6"
SQ   SEQUENCE   431 AA;  48340 MW;  B3D724F2099AD378 CRC64;
     MYRTKVGLKD RQQLYKLIIS QLLYDGYISI ANGLINEIKP QSVCAPSEQL LHLIKLGMEN
     DDTAVQYAIG RSDTVAPGTG IDLEFDADVQ TMSPEASEYE TCYVTSHKGP CRVATYSRDG
     QLIATGSADA SIKILDTERM LAKSAMPIEV MMNETAQQNM ENHPVIRTLY DHVDEVTCLA
     FHPTEQILAS GSRDYTLKLF DYSKPSAKRA FKYIQEAEML RSISFHPSGD FILVGTQHPT
     LRLYDINTFQ CFVSCNPQDQ HADAICSVNY NSSANMYVTG SKDGCIKLWD GVSNRCITTF
     EKAHDGAEVC SAIFSKNSKY ILSSGKDSVA KLWEISTGRT LVRYTGAGLS GRQVHRTQAV
     FNHTEDYVLL PDERTISLCC WDSRIAERRN LLSLGHNNIV RCIVHSPTNP GFMTCSDDFR
     ARFWYRRSTT D