ID   CSTF1_RAT               Reviewed;         431 AA.
AC   Q5BJQ6;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Cleavage stimulation factor subunit 1;
DE   AltName: Full=Cleavage stimulation factor 50 kDa subunit;
DE            Short=CSTF 50 kDa subunit;
DE            Short=CstF-50;
GN   Name=Cstf1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: One of the multiple factors required for polyadenylation and
CC       3'-end cleavage of mammalian pre-mRNAs (By similarity). May be
CC       responsible for the interaction of CSTF with other factors to form a
CC       stable complex on the pre-mRNA (By similarity).
CC       {ECO:0000250|UniProtKB:Q05048}.
CC   -!- SUBUNIT: Homodimer (By similarity). The CSTF complex is composed of
CC       CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa
CC       subunit) (By similarity). Interacts (via repeats WD) directly with
CC       CSTF3 (By similarity). Interacts (via repeat WD6) with BARD1 (By
CC       similarity). Interacts with ERCC6 (By similarity).
CC       {ECO:0000250|UniProtKB:Q05048}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q05048}.
CC   -!- DOMAIN: N-terminus mediates homodimerization.
CC       {ECO:0000250|UniProtKB:Q05048}.
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DR   EMBL; BC091381; AAH91381.1; -; mRNA.
DR   RefSeq; NP_001013179.1; NM_001013161.1.
DR   RefSeq; XP_006235743.2; XM_006235681.2.
DR   RefSeq; XP_006235744.1; XM_006235682.1.
DR   RefSeq; XP_006235745.1; XM_006235683.3.
DR   RefSeq; XP_006235746.1; XM_006235684.2.
DR   RefSeq; XP_006235747.1; XM_006235685.3.
DR   RefSeq; XP_006235748.1; XM_006235686.3.
DR   AlphaFoldDB; Q5BJQ6; -.
DR   SMR; Q5BJQ6; -.
DR   BioGRID; 260014; 1.
DR   IntAct; Q5BJQ6; 1.
DR   STRING; 10116.ENSRNOP00000051976; -.
DR   jPOST; Q5BJQ6; -.
DR   PaxDb; Q5BJQ6; -.
DR   PRIDE; Q5BJQ6; -.
DR   Ensembl; ENSRNOT00000055101; ENSRNOP00000051976; ENSRNOG00000004775.
DR   GeneID; 311670; -.
DR   KEGG; rno:311670; -.
DR   CTD; 1477; -.
DR   RGD; 1309267; Cstf1.
DR   eggNOG; KOG0640; Eukaryota.
DR   GeneTree; ENSGT00910000144253; -.
DR   HOGENOM; CLU_041619_0_0_1; -.
DR   InParanoid; Q5BJQ6; -.
DR   OMA; SNRCINT; -.
DR   OrthoDB; 587820at2759; -.
DR   PhylomeDB; Q5BJQ6; -.
DR   TreeFam; TF314234; -.
DR   Reactome; R-RNO-72163; mRNA Splicing - Major Pathway.
DR   Reactome; R-RNO-72187; mRNA 3'-end processing.
DR   Reactome; R-RNO-73856; RNA Polymerase II Transcription Termination.
DR   Reactome; R-RNO-77595; Processing of Intronless Pre-mRNAs.
DR   PRO; PR:Q5BJQ6; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000004775; Expressed in testis and 19 other tissues.
DR   Genevisible; Q5BJQ6; RN.
DR   GO; GO:0005848; C:mRNA cleavage stimulating factor complex; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0031124; P:mRNA 3'-end processing; IEA:InterPro.
DR   Gene3D; 1.20.960.50; -; 1.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR044633; CstF1-like.
DR   InterPro; IPR032028; CSTF1_dimer.
DR   InterPro; IPR038184; CSTF1_dimer_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR44133; PTHR44133; 1.
DR   Pfam; PF16699; CSTF1_dimer; 1.
DR   Pfam; PF00400; WD40; 5.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   mRNA processing; Nucleus; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..431
FT                   /note="Cleavage stimulation factor subunit 1"
FT                   /id="PRO_0000050947"
FT   REPEAT          106..145
FT                   /note="WD 1"
FT   REPEAT          171..210
FT                   /note="WD 2"
FT   REPEAT          215..254
FT                   /note="WD 3"
FT   REPEAT          260..301
FT                   /note="WD 4"
FT   REPEAT          303..343
FT                   /note="WD 5"
FT   REPEAT          395..431
FT                   /note="WD 6"
SQ   SEQUENCE   431 AA;  48382 MW;  8BD7BEFE422824D2 CRC64;
     MYRTKVGLKD RQQLYKLIIS QLLYDGYISI ANGLINEIKP QSVCAPSEQL LHLIKLGMEN
     DDTAVQYAIG RSDTVAPGTG IDLEFDADVQ TMSPEASEYE TCYVTSHKGP CRVATYSRDG
     QLIATGSADA SIKILDTERM LAKSAMPIEV MMNETAQQNM ENHPVIRTLY DHVDEVTCLA
     FHPTEQILAS GSRDYTLKLF DYSKPSAKRA FKYIQEAEML RSISFHPSGD FILVGTQHPT
     LRLYDINTFQ CFVSCNPQDQ HTDAICSVNY NPSANMYVTG SKDGCIKLWD GVSNRCITTF
     EKAHDGAEVC SAIFSKNSKY ILSSGKDSVA KLWEISTGRT LVRYTGAGLS GRQVHRTQAV
     FNHTEDYILL PDERTISLCC WDSRTAERRN LLSLGHNNIV RCIVHSPTNP GFMTCSDDFR
     ARFWYRRSTT D