ID   CSTF3_PONAB             Reviewed;         717 AA.
AC   Q5RDW9;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Cleavage stimulation factor subunit 3;
DE   AltName: Full=CF-1 77 kDa subunit;
DE   AltName: Full=Cleavage stimulation factor 77 kDa subunit;
DE            Short=CSTF 77 kDa subunit;
DE            Short=CstF-77;
GN   Name=CSTF3;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: One of the multiple factors required for polyadenylation and
CC       3'-end cleavage of mammalian pre-mRNAs. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. The CSTF complex is composed of CSTF1 (50 kDa
CC       subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). CSTF3
CC       directly interacts with CSTF1 and CSTF2. Interacts with FIP1L1 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; CR857774; CAH90038.1; -; mRNA.
DR   RefSeq; NP_001127228.1; NM_001133756.1.
DR   AlphaFoldDB; Q5RDW9; -.
DR   SMR; Q5RDW9; -.
DR   STRING; 9601.ENSPPYP00000003876; -.
DR   GeneID; 100174283; -.
DR   KEGG; pon:100174283; -.
DR   CTD; 1479; -.
DR   eggNOG; KOG1914; Eukaryota.
DR   InParanoid; Q5RDW9; -.
DR   OrthoDB; 331411at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031124; P:mRNA 3'-end processing; IEA:InterPro.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR045243; Rna14-like.
DR   InterPro; IPR008847; Suf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR19980; PTHR19980; 1.
DR   Pfam; PF05843; Suf; 1.
DR   SMART; SM00386; HAT; 10.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; mRNA processing; Nucleus; Phosphoprotein; Reference proteome;
KW   Repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q12996"
FT   CHAIN           2..717
FT                   /note="Cleavage stimulation factor subunit 3"
FT                   /id="PRO_0000205724"
FT   REPEAT          45..77
FT                   /note="HAT 1"
FT   REPEAT          79..110
FT                   /note="HAT 2"
FT   REPEAT          117..152
FT                   /note="HAT 3"
FT   REPEAT          163..196
FT                   /note="HAT 4"
FT   REPEAT          221..261
FT                   /note="HAT 5"
FT   REPEAT          271..303
FT                   /note="HAT 6"
FT   REPEAT          319..352
FT                   /note="HAT 7"
FT   REPEAT          354..387
FT                   /note="HAT 8"
FT   REPEAT          458..494
FT                   /note="HAT 9"
FT   REGION          684..705
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        685..702
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q12996"
FT   MOD_RES         691
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q12996"
SQ   SEQUENCE   717 AA;  82910 MW;  A03C9D45466AE894 CRC64;
     MSGDGATEQA AEYVPEKVKK AEKKLEENPY DLDAWSTLIR EAQNQPIDKA RKTYERLVAQ
     FPSSGRFWKL YIEAEIKAKN YDKVEKLFQR CLMKVLHIDL WKCYLSYVRE TKGKLPSYKE
     KMAQAYDFAL DKIGMEIMSY QIWVDYINFL KGVEAVGSYA ENQRITAVRR VYQRGCVNPM
     INIEQLWRDY NKYEEGINIH LAKKMIEDRS RDYMNARRVA KEYETVMKGL DRNAPSVPPQ
     NTPQEAQQVD MWKKYIQWEK SNPLRTEDQT LITKRVMFAY EQCLLVLGHH PDIWYEAAQY
     LEQSSKLLAE KGDMNNAKLF SDEAANIYER AISTLLKKNM LLYFAYADYE ESRMKYEKVH
     SIYNRLLAIE DIDPTLVYIQ YMKFARRAEG IKSGRMIFKK AREDTRTRHH VYVTAALMEY
     YCSKDKSVAF KIFELGLKKY GDIPEYVLAY IDYLSHLNED NNTRVLFERV LTSGSLPPEK
     SGEIWARFLA FESNIGDLAS ILKVEKRRFT AFKEEYEGKE TALLVDRYKF MDLYPCSASE
     LKALGYKDVS RAKLAAIIPD PVVAPSIVPV LKDEVDRKPE YPKPDTQQMI PFQPRHLAPP
     GLHPVPGGVF PVPPAAVVLM KLLPPPICFQ GPFVQVDELM EIFRRCKIPN TVEEAVRIIT
     GGAPELAVEG NGPVESNAVL TKAVKRPNED SDEDEEKGAV VPPVHDIYRA RQQKRIR